Diagnostic framing of IgM monoclonal gammopathy: Focus on Waldenström macroglobulinemia

Alessandra Tedeschi, Concetta Conticello, Rita Rizzi, Giulia Benevolo, Luca Laurenti, Maria Teresa Petrucci, Francesco Zaja, Marzia Varettoni

Research output: Contribution to journalArticle

Abstract

The finding of an IgM monoclonal gammopathy often represents a diagnostic challenge. In fact, there are many pathological disorders associated with this condition, each of which has distinctive characteristics and requires specific clinical, instrumental, and laboratory assessments to set the appropriate treatment. This review has two aims. Firstly, to provide a framework of the broad spectrum of IgM-associated disorders: (1) monoclonal gammopathy of undetermined significance (MGUS); (2) Waldenström macroglobulinemia (WM); (3) IgM-related disorders (among which hyperviscosity syndrome, light chain amyloidosis, cold agglutinin disease, cryoglobulinaemia, IgM neuropathy, Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome, Castleman disease); (4) IgM-secreting multiple myeloma (IgM-MM); and (5) other lymphoproliferative disorders which may be associated with IgM (such as chronic lymphocytic leukemia, small lymphocytic lymphoma, and B-cell non Hodgkin lymphoma). Secondly, to give a detailed insight regarding diagnosis and treatment of WM.
Original languageEnglish
Pages (from-to)117-128
Number of pages12
JournalHematological Oncology
Volume37
Issue number2
DOIs
Publication statusPublished - Apr 2019

Keywords

  • IgM monoclonal gammopathy
  • IgM-related disorders
  • IgM-secreting multiple myeloma
  • Waldenström macroglobulinemia
  • Humans
  • *Monoclonal Gammopathy of Undetermined Significance/blood/diagnosis/therapy
  • *Waldenstrom Macroglobulinemia/blood/diagnosis/therapy

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