Diagnostic immunohistochemistry in gynaecological neoplasia: a brief survey of the most common scenarios

Elisabetta Kuhn, Ayse Ayhan

Research output: Contribution to journalReview articlepeer-review


Immunohistochemistry is a valuable adjunct in routine gynaecological pathology. The molecular revolution has redesigned knowledge of gynaecological cancers and refined histological classification. The direct consequence has been the progressive introduction of new immunostainings for diagnostic and classification purposes. Hence, we review the routine diagnostic use of immunohistochemistry in the field of gynaecological neoplasia. We reviewed the immunomarkers useful in gynaecological pathology according to literature revision, our personal experience and research findings. We discuss the application of immunohistochemistry to reach the most accurate diagnosis in morphologically equivocal cases of gynaecological pathology and present the appropriate panel of immunomarkers in the most common scenarios of gynaecological pathology. This short review provides an updated overview of the essential immunohistochemical markers currently used in the diagnostics of gynaecological malignancies along with their molecular rationale.

Original languageEnglish
Pages (from-to)98-109
Number of pages12
JournalJournal of Clinical Pathology
Issue number2
Publication statusPublished - Feb 1 2018


  • diagnosis
  • diagnostics
  • gynaecological pathology
  • immunohistochemistry
  • ovarian tumour

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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