In this study the authors found the presence of circulating autoantibodies belonging to all types described in literature in the serum of hepatopatients, without a particular preference for a single liver disease. This fact lead them to believe that the presence of autoantibodies in the serum of patients affected by evolutive chronic liver diseases might represent only the symptom of an autoimmunitary process due to the thymus dependent system. This is in agreement with Almeida's and Waterson's studies on the pathogenetical role of the immunocomplexes and with Dudley's studies on the importance, in the maintenance of the hepatic damage, of the lymphocyte response correlated to the thymus dependent system. Although they do not have any pathogenetical meaning, these autoantibodies do certainly have a physiopathologic and diagnostic value. They indicate, in fact, the existence of an evolutive pathological process. This process is often started by a viral hepatitis (sometimes not mentioned by the patient) and, less frequently, by dietetic factors, by colostasis or by a neoplastic process. It would be maintained by the immunity correlated to the thymus dependent system, and serum autoantibodies would be its most evident diagnostic sign.
|Translated title of the contribution||Diagnostic meaning of autoantibodies in the serum of hepatopatic patients|
|Title of host publication||Archivio E. Maragliano di Patologia e Clinica|
|Number of pages||9|
|Publication status||Published - 1974|
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