Diagnostic performance and prognostic role of FDG PET/CT performed at staging in anal cancer

Lucia Leccisotti, D. Ripani, S. Manfrida, A. Giordano

Research output: Contribution to journalReview articlepeer-review

Abstract

Aim: This mini-review aims to analyse the diagnostic performance and the prognostic role of FDG PET/CT performed at staging in anal cancer patients by the analysis of published literature. Materials and methods: A comprehensive computer literature search of studies published on PubMed/Medline database in the last 10 years was carried out. Sensitivity and specificity of FDG PET/CT performed at staging respect to the final diagnosis of nodal status and/or distant metastases and the prognostic significance of staging metabolic parameters were analysed. Results: Twenty articles were included, 10 (50%) on diagnostic performance and 10 (50%) on the prognostic role of FDG PET/CT, respectively. The sensitivity and the specificity of FDG PET/CT performed at staging for lymph node metastases ranged from 22 to 100% and from 53 to 100%, respectively. For distant metastases, sensitivity and specificity of FDG PET/CT performed at staging were of 100%. One or more PET parameters resulted to be significantly related to prognosis in 8/10 (80%) studies. Conclusions: FDG PET/CT performed at staging has a good diagnostic performance in anal cancer patients. Some baseline metabolic parameters seem to have also a prognostic significance. Further research is required to validate these results.

Original languageEnglish
Pages (from-to)55-64
Number of pages10
JournalClinical and Translational Imaging
Volume8
Issue number2
DOIs
Publication statusPublished - Apr 1 2020

Keywords

  • Anal cancer
  • FDG
  • PET
  • PET/CT
  • Prognosis
  • Staging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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