TY - JOUR
T1 - Diagnostic performance of coronary CT angiography carried out with a novel whole-heart coverage high-definition CT scanner in patients with high heart rate
AU - Andreini, Daniele
AU - Mushtaq, Saima
AU - Pontone, Gianluca
AU - Conte, Edoardo
AU - Guglielmo, Marco
AU - Annoni, Andrea
AU - Baggiano, Andrea
AU - Formenti, Alberto
AU - Ditali, Valentina
AU - Mancini, Maria Elisabetta
AU - Zanchi, Simone
AU - Melotti, Eleonora
AU - Trabattoni, Daniela
AU - Montorsi, Piero
AU - Ravagnani, Paolo Mario
AU - Fiorentini, Cesare
AU - Bartorelli, Antonio L
AU - Pepi, Mauro
N1 - Copyright © 2017 Elsevier B.V. All rights reserved.
PY - 2018/4/15
Y1 - 2018/4/15
N2 - BACKGROUND: Aim of the study was to evaluate image quality, radiation exposure and diagnostic accuracy of coronary CT angiography (CCTA) performed with a novel cardiac CT scanner in patients with very high heart rate (HR).METHODS: We prospectively enrolled 202 patients (111 men, mean age 66±8years) with suspected coronary artery disease who underwent CCTA with a whole-organ volumetric CT scanner. The HR during the scan was ≥80bpm in 100 patients (Group 1), while it was ≤65bpm in the remaining 102 patients (Group 2). In all patients, image quality score and coronary interpretability were evaluated and effective dose (ED) was recorded. In 86 of the 202 enrolled patients (40 patients in Group 1, 46 patients in Group 2) who were referred for a clinically indicated invasive coronary angiography (ICA) within 6months, diagnostic accuracy of CCTA vs. ICA was evaluated.RESULTS: Mean image quality and coronary interpretability were very high in both Groups (Likert=3.35 vs. 3.39 and 97.3% [1542/1584 segments] and 98% [1569/1600 segments] in Group 1 and Group 2, respectively). Mean ED was lower in Group 2 (1.1±0.5mSv) compared to Group 1 (2.9±1.6mSv). In Group 1, sensitivity and specificity of CCTA for detection of >50% stenosis vs. ICA were 95.2% and 98.9% in a segment-based analysis and 100% and 81.8% in a patient-based analysis, respectively.CONCLUSIONS: The whole organ high-definition CT scanner allows evaluating coronary arteries in patients with high HR with excellent image quality, coronary interpretability and low radiation exposure.
AB - BACKGROUND: Aim of the study was to evaluate image quality, radiation exposure and diagnostic accuracy of coronary CT angiography (CCTA) performed with a novel cardiac CT scanner in patients with very high heart rate (HR).METHODS: We prospectively enrolled 202 patients (111 men, mean age 66±8years) with suspected coronary artery disease who underwent CCTA with a whole-organ volumetric CT scanner. The HR during the scan was ≥80bpm in 100 patients (Group 1), while it was ≤65bpm in the remaining 102 patients (Group 2). In all patients, image quality score and coronary interpretability were evaluated and effective dose (ED) was recorded. In 86 of the 202 enrolled patients (40 patients in Group 1, 46 patients in Group 2) who were referred for a clinically indicated invasive coronary angiography (ICA) within 6months, diagnostic accuracy of CCTA vs. ICA was evaluated.RESULTS: Mean image quality and coronary interpretability were very high in both Groups (Likert=3.35 vs. 3.39 and 97.3% [1542/1584 segments] and 98% [1569/1600 segments] in Group 1 and Group 2, respectively). Mean ED was lower in Group 2 (1.1±0.5mSv) compared to Group 1 (2.9±1.6mSv). In Group 1, sensitivity and specificity of CCTA for detection of >50% stenosis vs. ICA were 95.2% and 98.9% in a segment-based analysis and 100% and 81.8% in a patient-based analysis, respectively.CONCLUSIONS: The whole organ high-definition CT scanner allows evaluating coronary arteries in patients with high HR with excellent image quality, coronary interpretability and low radiation exposure.
KW - Aged
KW - Computed Tomography Angiography/methods
KW - Coronary Artery Disease/diagnostic imaging
KW - Female
KW - Heart Rate/physiology
KW - Humans
KW - Male
KW - Middle Aged
KW - Prospective Studies
KW - Single-Blind Method
KW - Tomography Scanners, X-Ray Computed/standards
U2 - 10.1016/j.ijcard.2017.10.084
DO - 10.1016/j.ijcard.2017.10.084
M3 - Article
C2 - 29506722
VL - 257
SP - 325
EP - 331
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -