Diagnostic performance of new and classic CSF biomarkers in age-related dementias

Francesca Marchegiani, Giulia Matacchione, Deborah Ramini, Fiorella Marcheselli, Rina Recchioni, Tiziana Casoli, Elisa Mercuri, Marco Lazzarini, Belinda Giorgetti, Valentina Cameriere, Susy Paolini, Lucia Paciaroni, Tommaso Rossi, Roberta Galeazzi, Rosamaria Lisa, Anna Rita Bonfigli, Antonio Domenico Procopio, Maria De Luca, Giuseppe Pelliccioni, Fabiola Olivieri

Research output: Contribution to journalArticle

Abstract

The identification of diagnostic-prognostic biomarkers of dementia has become a global priority due to the prevalence of neurodegenerative diseases in aging populations. The objective of this study was to assess the diagnostic performance of cerebrospinal fluid (CSF) biomarkers across patients affected by either Alzheimer's disease (AD), tauopathies other than AD (TP), or vascular dementia (VD), and cognitively normal subjects (CNS). One hundred fifty-three patients were recruited and tested for classical AD CSF biomarkers- Amyloid-ß42 and tau proteins - and novel candidate biomarkers - neurofilament (NF-) light and microRNA (miR) -21, -125b, -146a, and -222. All dementia patients had significantly higher concentrations of NF-light compared to CNS, with the TP group displaying the highest NF-light values. A significant inverse correlation was also observed between NF-light and cognitive impairment. Of the four miRNAs analyzed, miR-222 levels were significantly increased in VD patients compared to both CNS and AD. In addition, while NF-light showed a better diagnostic performance than miR-222 and classical AD biomarkers in differentiating TP and VD from CNS, classical AD biomarkers revealed higher performance in discriminating AD from non-AD disorders. Overall, our results suggest that CSF NF-light and miR-222 are promising biomarkers that may help to diagnose non-AD disorders.

Original languageEnglish
Pages (from-to)2420-2429
Number of pages10
JournalAging
Volume11
Issue number8
DOIs
Publication statusPublished - Apr 30 2019

Keywords

  • Age-related dementias
  • CSF
  • MicroRNAs
  • Neurofilament-light

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

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