Diagnostic performance of PET/MR in the evaluation of active inflammation in Crohn disease

Onofrio Antonio Catalano; Vincent Wu; Umar Mahmood; Alberto Signore; Mark Vangel; Andrea Soricelli; Marco Salvatore; Debra Gervais; Bruce R Rosen

Diagnostic performance of PET/MR in the evaluation of active inflammation in Crohn disease

Onofrio Antonio Catalano, Vincent Wu, Umar Mahmood, Alberto Signore, Mark Vangel, Andrea Soricelli, Marco Salvatore, Debra Gervais, Bruce R Rosen

IRCCS SDN

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Specificity for active inflammation was 74% for PET, 87% for MR, and 93% for PET/MR. Diagnostic accuracy was 84% for PET, 83% for MR, and 91% for PET/MR. In conclusion, PET/MR is significantly more accurate than either sub-modality alone and more specific than PET alone in the detection of active inflammation in patients with Crohn disease.

Original language	English
Pages (from-to)	62-69
Number of pages	8
Journal	American Journal of Nuclear Medicine and Molecular Imaging
Volume	8
Issue number	1
Publication status	Published - 2018

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Diagnostic performance of PET/MR in the evaluation of active inflammation in Crohn disease. / Catalano, Onofrio Antonio; Wu, Vincent; Mahmood, Umar; Signore, Alberto; Vangel, Mark; Soricelli, Andrea ; Salvatore, Marco; Gervais, Debra; Rosen, Bruce R.

In: American Journal of Nuclear Medicine and Molecular Imaging, Vol. 8, No. 1, 2018, p. 62-69.

Research output: Contribution to journal › Article › peer-review

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abstract = "This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Specificity for active inflammation was 74% for PET, 87% for MR, and 93% for PET/MR. Diagnostic accuracy was 84% for PET, 83% for MR, and 91% for PET/MR. In conclusion, PET/MR is significantly more accurate than either sub-modality alone and more specific than PET alone in the detection of active inflammation in patients with Crohn disease.",

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AU - Catalano, Onofrio Antonio

AU - Wu, Vincent

AU - Mahmood, Umar

AU - Signore, Alberto

AU - Vangel, Mark

AU - Soricelli, Andrea

AU - Salvatore, Marco

AU - Gervais, Debra

AU - Rosen, Bruce R

PY - 2018

Y1 - 2018

N2 - This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Specificity for active inflammation was 74% for PET, 87% for MR, and 93% for PET/MR. Diagnostic accuracy was 84% for PET, 83% for MR, and 91% for PET/MR. In conclusion, PET/MR is significantly more accurate than either sub-modality alone and more specific than PET alone in the detection of active inflammation in patients with Crohn disease.

AB - This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Specificity for active inflammation was 74% for PET, 87% for MR, and 93% for PET/MR. Diagnostic accuracy was 84% for PET, 83% for MR, and 91% for PET/MR. In conclusion, PET/MR is significantly more accurate than either sub-modality alone and more specific than PET alone in the detection of active inflammation in patients with Crohn disease.

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JO - American Journal of Nuclear Medicine and Molecular Imaging

JF - American Journal of Nuclear Medicine and Molecular Imaging

SN - 2160-8407

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