Diagnostic performance of PET/MR in the evaluation of active inflammation in Crohn disease

Onofrio Antonio Catalano, Vincent Wu, Umar Mahmood, Alberto Signore, Mark Vangel, Andrea Soricelli, Marco Salvatore, Debra Gervais, Bruce R Rosen

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Specificity for active inflammation was 74% for PET, 87% for MR, and 93% for PET/MR. Diagnostic accuracy was 84% for PET, 83% for MR, and 91% for PET/MR. In conclusion, PET/MR is significantly more accurate than either sub-modality alone and more specific than PET alone in the detection of active inflammation in patients with Crohn disease.

Original languageEnglish
Pages (from-to)62-69
Number of pages8
JournalAmerican Journal of Nuclear Medicine and Molecular Imaging
Volume8
Issue number1
Publication statusPublished - 2018

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