Diagnostic performances of the Xpert MTB/RIF in Brazil

Denise Rossato Silva, Giovanni Sotgiu, Lia D'Ambrosio, Giovana Rodrigues Pereira, Márcia Silva Barbosa, Natan José Dutra Dias, Laura Saderi, Rosella Centis, Giovanni Battista Migliori

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND OBJECTIVES: As for all tests, the diagnostic performances of Xpert MTB/RIF might be different in settings with different tuberculosis prevalence. Aim of the study is to evaluate the performances of Xpert MTB/RIF to diagnose tuberculosis in Brazil, where 407 culture-confirmed tuberculosis patients were retrospectively enrolled in Rio Grande do Sul, between 2015 and 2016.

METHODS: Sensitivity, specificity, positive and negative predictive values of the test were calculated and a logistic regression analysis was performed to assess the role played by explanatory variables in the occurrence of true positive and negative diagnostic results.

RESULTS: Sensitivity of Xpert MTB/RIF was 100.0%, specificity 92.8%; positive and negative predictive values were 71.4% and 100.0%, respectively. In the HIV- infected sub-group specificity was 59.3%. In the multivariate logistic regression analysis, true positivity was associated with increasing age (1.0; p-value: 0.02) while true positivity and negativity were negatively associated with alcohol abuse.

CONCLUSIONS: Xpert is sensitive and specific in the Brasilian settings.

Original languageEnglish
Pages (from-to)12-15
Number of pages4
JournalRespiratory Medicine
Volume134
DOIs
Publication statusPublished - Jan 2018

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    Silva, D. R., Sotgiu, G., D'Ambrosio, L., Pereira, G. R., Barbosa, M. S., Dias, N. J. D., Saderi, L., Centis, R., & Migliori, G. B. (2018). Diagnostic performances of the Xpert MTB/RIF in Brazil. Respiratory Medicine, 134, 12-15. https://doi.org/10.1016/j.rmed.2017.11.012