Abstract
Background: Geriatric patients with acute non-ST elevation myocardial infarction (NSTEMI) can frequently present atypical symptoms and non-diagnostic electrocardiogram. The detection of modest cardiac troponin T (cTnT) elevation is challenging for physicians needing to routinely triage these patients. Unfortunately, non-coronary diseases, such as acute heart failure (CHF), may cause cTnT elevation. Circulating microRNAs (miRs) have emerged as biomarkers of MI. However, their diagnostic potential needs to be determined in elderly NSTEMI patients. Methods: 92 NSTEMI patients (82.6 ± 6.9 years old; complicated by CHF in 74% of cases) and 81 patients with acute CHF without AMI (81.3 ± 6.8 years old) were enrolled at presentation. A third group comprised 99 age-matched healthy control subjects (CTR). Plasma levels of miR-1, -21, -133a, -208a, -423-5p and -499-5p were analyzed. Results: MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited > 80-fold increase in acute NSTEMI patient vs. CTR. MiR-499-5p and -21 showed a significantly increased expression in NSTEMI vs. CHF. Interestingly, mir-499-5p was comparable to cTnT in discriminating NSTEMI vs. CTR and CHF patients. Its diagnostic accuracy was higher than conventional and hs-cTnT in differentiating NSTEMI (n = 31) vs. acute CHF (n = 32) patients with modest cTnT elevation at presentation (miR-499-5p AUC = 0.86 vs. cTnT AUC = 0.68 and vs. hs-cTnT AUC = 0.70). Conclusions: Circulating miR-499-5p is a sensitive biomarker of acute NSTEMI in the elderly, exhibiting a diagnostic accuracy superior to that of cTnT in patients with modest elevation at presentation.
| Original language | English |
|---|---|
| Pages (from-to) | 531-536 |
| Number of pages | 6 |
| Journal | International Journal of Cardiology |
| Volume | 167 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jul 31 2013 |
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Keywords
- Aging
- Biomarkers
- Circulating microRNAs
- Heart failure
- Myocardial infarction
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction. / Olivieri, Fabiola; Antonicelli, Roberto; Lorenzi, Maria; D'Alessandra, Yuri; Lazzarini, Raffaella; Santini, Gabriele; Spazzafumo, Liana; Lisa, Rosamaria; La Sala, Lucia; Galeazzi, Roberta; Recchioni, Rina; Testa, Roberto; Pompilio, Giulio; Capogrossi, Maurizio C.; Procopio, Antonio Domenico.
In: International Journal of Cardiology, Vol. 167, No. 2, 31.07.2013, p. 531-536.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction
AU - Olivieri, Fabiola
AU - Antonicelli, Roberto
AU - Lorenzi, Maria
AU - D'Alessandra, Yuri
AU - Lazzarini, Raffaella
AU - Santini, Gabriele
AU - Spazzafumo, Liana
AU - Lisa, Rosamaria
AU - La Sala, Lucia
AU - Galeazzi, Roberta
AU - Recchioni, Rina
AU - Testa, Roberto
AU - Pompilio, Giulio
AU - Capogrossi, Maurizio C.
AU - Procopio, Antonio Domenico
PY - 2013/7/31
Y1 - 2013/7/31
N2 - Background: Geriatric patients with acute non-ST elevation myocardial infarction (NSTEMI) can frequently present atypical symptoms and non-diagnostic electrocardiogram. The detection of modest cardiac troponin T (cTnT) elevation is challenging for physicians needing to routinely triage these patients. Unfortunately, non-coronary diseases, such as acute heart failure (CHF), may cause cTnT elevation. Circulating microRNAs (miRs) have emerged as biomarkers of MI. However, their diagnostic potential needs to be determined in elderly NSTEMI patients. Methods: 92 NSTEMI patients (82.6 ± 6.9 years old; complicated by CHF in 74% of cases) and 81 patients with acute CHF without AMI (81.3 ± 6.8 years old) were enrolled at presentation. A third group comprised 99 age-matched healthy control subjects (CTR). Plasma levels of miR-1, -21, -133a, -208a, -423-5p and -499-5p were analyzed. Results: MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited > 80-fold increase in acute NSTEMI patient vs. CTR. MiR-499-5p and -21 showed a significantly increased expression in NSTEMI vs. CHF. Interestingly, mir-499-5p was comparable to cTnT in discriminating NSTEMI vs. CTR and CHF patients. Its diagnostic accuracy was higher than conventional and hs-cTnT in differentiating NSTEMI (n = 31) vs. acute CHF (n = 32) patients with modest cTnT elevation at presentation (miR-499-5p AUC = 0.86 vs. cTnT AUC = 0.68 and vs. hs-cTnT AUC = 0.70). Conclusions: Circulating miR-499-5p is a sensitive biomarker of acute NSTEMI in the elderly, exhibiting a diagnostic accuracy superior to that of cTnT in patients with modest elevation at presentation.
AB - Background: Geriatric patients with acute non-ST elevation myocardial infarction (NSTEMI) can frequently present atypical symptoms and non-diagnostic electrocardiogram. The detection of modest cardiac troponin T (cTnT) elevation is challenging for physicians needing to routinely triage these patients. Unfortunately, non-coronary diseases, such as acute heart failure (CHF), may cause cTnT elevation. Circulating microRNAs (miRs) have emerged as biomarkers of MI. However, their diagnostic potential needs to be determined in elderly NSTEMI patients. Methods: 92 NSTEMI patients (82.6 ± 6.9 years old; complicated by CHF in 74% of cases) and 81 patients with acute CHF without AMI (81.3 ± 6.8 years old) were enrolled at presentation. A third group comprised 99 age-matched healthy control subjects (CTR). Plasma levels of miR-1, -21, -133a, -208a, -423-5p and -499-5p were analyzed. Results: MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited > 80-fold increase in acute NSTEMI patient vs. CTR. MiR-499-5p and -21 showed a significantly increased expression in NSTEMI vs. CHF. Interestingly, mir-499-5p was comparable to cTnT in discriminating NSTEMI vs. CTR and CHF patients. Its diagnostic accuracy was higher than conventional and hs-cTnT in differentiating NSTEMI (n = 31) vs. acute CHF (n = 32) patients with modest cTnT elevation at presentation (miR-499-5p AUC = 0.86 vs. cTnT AUC = 0.68 and vs. hs-cTnT AUC = 0.70). Conclusions: Circulating miR-499-5p is a sensitive biomarker of acute NSTEMI in the elderly, exhibiting a diagnostic accuracy superior to that of cTnT in patients with modest elevation at presentation.
KW - Aging
KW - Biomarkers
KW - Circulating microRNAs
KW - Heart failure
KW - Myocardial infarction
UR - http://www.scopus.com/inward/record.url?scp=84879119108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879119108&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2012.01.075
DO - 10.1016/j.ijcard.2012.01.075
M3 - Article
VL - 167
SP - 531
EP - 536
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 2
ER -