Diagnostic procedures in the follow-up of patients affected by men type 2

Ettore Seregni; Federica Pallotti; Franco Mattavelli; Leonardo Ferrari; Antonia Martinetti; Gianluca Aliberti; Carlo Villano; Maria Rita Castellani; Emilio Bombardieri

Diagnostic procedures in the follow-up of patients affected by men type 2

Ettore Seregni, Federica Pallotti, Franco Mattavelli, Leonardo Ferrari, Antonia Martinetti, Gianluca Aliberti, Carlo Villano, Maria Rita Castellani, Emilio Bombardieri

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Multiple endocrine neoplasia type 2 (MEN 2) is an inherited disease caused by germline mutations in the RET proto-oncogene. The most distinctive MEN 2 variants are MEN 2A, MEN 2B and familial medullary thyroid cancer (FMTC). The hallmark of these syndromes is the development of medullary thyroid carcinoma (MTC), which occurs in almost all patients with MEN 2 syndromes. Other endocrinopathies are variably expressed. Pheochromocytoma and hyperparathyroidism occur in patients with MEN 2A with a frequency of about 50% and 30%, respectlvely. In this paper we summarize the most relevant diagnostic methods to detect and monitor MTC, pheochromocytoma and hyperparathyroidism.

Original language	English
Pages (from-to)	563-565
Number of pages	3
Journal	Tumori
Volume	89
Issue number	5
Publication status	Published - Sep 2003

Keywords

Hyperparathyroidism
Medullary thyroid carcinoma (MTC)
MEN 2 syndromes
Pheochromocytoma

ASJC Scopus subject areas

Cancer Research

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Diagnostic procedures in the follow-up of patients affected by men type 2. / Seregni, Ettore; Pallotti, Federica; Mattavelli, Franco; Ferrari, Leonardo; Martinetti, Antonia; Aliberti, Gianluca; Villano, Carlo; Castellani, Maria Rita; Bombardieri, Emilio.

In: Tumori, Vol. 89, No. 5, 09.2003, p. 563-565.

Research output: Contribution to journal › Article › peer-review

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