Diagnostic sensitivity of thyroid autoantibodies assessed in a population-based, cross-sectional study in adults

Emanuele Bosi, Roberto Bianchi, Giacomo Ruotolo, Elena Bazzigaluppi, Cristina Belloni, Giliola Calori, Anna Maria Girardi, Maria Paola Garancini, Marina Scavini

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to estimate the diagnostic sensitivity of thyroid autoantibodies in individuals with a case-mix of subjects with thyroid disease representing that of the general population. We measured thyroid microsome (TMA), thyroid peroxidase (TPO), thyroglobulin (TGA) and thyroid-stimulating hormone(TSH) receptor (TRA) autoantibodies in subjects in thebottom (hyperthyroid end) and top (hypothyroid end) fourpercentiles of the TSH distribution from among participantsin a population-based survey of individuals aged ≥40 years (the Cremona Study). TMA and TPO were the most sensitive autoantibodies in subjects in both the bottom percentiles (19.8% and 18.5%, respectively) and the top percentiles (51.2% and 53.8%, respectively) of the TSH distribution. TMA and TPO showed good agreement (kappa statistics 87.8%, 95% CI 80.1-95.5%) at both ends of the TSH distribution. TGA were the next most sensitive marker, although seldom detected if TMA orTPO were not present. TRA were detected only at theextremes of the TSH distribution (1st percentile, 31.8%;100th percentile, 25.0%). We conclude that, among a case-mix of individuals with thyroid disease representing that of the general population, TMA and TPO are the most sensitive markers of thyroid disease. TGA only marginally increased the diagnostic sensitivity of TMA and TPO. TRA are sensitive markers of thyroid diseaseonly at the extremes of thyroid function.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalAutoimmunity Highlights
Volume1
Issue number2
DOIs
Publication statusPublished - Nov 2010

Keywords

  • Autoantibody screening
  • Autoimmune thyroid disease
  • Population-based studies
  • Thyroid autoantibodies
  • Thyroid disease

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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