TY - JOUR
T1 - Diagnostic sensitivity of thyroid autoantibodies assessed in a population-based, cross-sectional study in adults
AU - Bosi, Emanuele
AU - Bianchi, Roberto
AU - Ruotolo, Giacomo
AU - Bazzigaluppi, Elena
AU - Belloni, Cristina
AU - Calori, Giliola
AU - Girardi, Anna Maria
AU - Garancini, Maria Paola
AU - Scavini, Marina
PY - 2010/11
Y1 - 2010/11
N2 - The aim of this study was to estimate the diagnostic sensitivity of thyroid autoantibodies in individuals with a case-mix of subjects with thyroid disease representing that of the general population. We measured thyroid microsome (TMA), thyroid peroxidase (TPO), thyroglobulin (TGA) and thyroid-stimulating hormone(TSH) receptor (TRA) autoantibodies in subjects in thebottom (hyperthyroid end) and top (hypothyroid end) fourpercentiles of the TSH distribution from among participantsin a population-based survey of individuals aged ≥40 years (the Cremona Study). TMA and TPO were the most sensitive autoantibodies in subjects in both the bottom percentiles (19.8% and 18.5%, respectively) and the top percentiles (51.2% and 53.8%, respectively) of the TSH distribution. TMA and TPO showed good agreement (kappa statistics 87.8%, 95% CI 80.1-95.5%) at both ends of the TSH distribution. TGA were the next most sensitive marker, although seldom detected if TMA orTPO were not present. TRA were detected only at theextremes of the TSH distribution (1st percentile, 31.8%;100th percentile, 25.0%). We conclude that, among a case-mix of individuals with thyroid disease representing that of the general population, TMA and TPO are the most sensitive markers of thyroid disease. TGA only marginally increased the diagnostic sensitivity of TMA and TPO. TRA are sensitive markers of thyroid diseaseonly at the extremes of thyroid function.
AB - The aim of this study was to estimate the diagnostic sensitivity of thyroid autoantibodies in individuals with a case-mix of subjects with thyroid disease representing that of the general population. We measured thyroid microsome (TMA), thyroid peroxidase (TPO), thyroglobulin (TGA) and thyroid-stimulating hormone(TSH) receptor (TRA) autoantibodies in subjects in thebottom (hyperthyroid end) and top (hypothyroid end) fourpercentiles of the TSH distribution from among participantsin a population-based survey of individuals aged ≥40 years (the Cremona Study). TMA and TPO were the most sensitive autoantibodies in subjects in both the bottom percentiles (19.8% and 18.5%, respectively) and the top percentiles (51.2% and 53.8%, respectively) of the TSH distribution. TMA and TPO showed good agreement (kappa statistics 87.8%, 95% CI 80.1-95.5%) at both ends of the TSH distribution. TGA were the next most sensitive marker, although seldom detected if TMA orTPO were not present. TRA were detected only at theextremes of the TSH distribution (1st percentile, 31.8%;100th percentile, 25.0%). We conclude that, among a case-mix of individuals with thyroid disease representing that of the general population, TMA and TPO are the most sensitive markers of thyroid disease. TGA only marginally increased the diagnostic sensitivity of TMA and TPO. TRA are sensitive markers of thyroid diseaseonly at the extremes of thyroid function.
KW - Autoantibody screening
KW - Autoimmune thyroid disease
KW - Population-based studies
KW - Thyroid autoantibodies
KW - Thyroid disease
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U2 - 10.1007/s13317-010-0012-6
DO - 10.1007/s13317-010-0012-6
M3 - Article
AN - SCOPUS:79960044488
VL - 1
SP - 83
EP - 86
JO - Autoimmunity Highlights
JF - Autoimmunity Highlights
SN - 2038-0305
IS - 2
ER -