Although an accurate lymphoma diagnosis still relies on histologic evaluation, several immunologic and molecular techniques are now available for diagnosis and classification of malignant hematologic disorders. In particular, sensitive and specific techniques have been developed for labeling antigens in tissue sections, whereas the use of monoclonal antibodies with flow cytometry has greatly facilitated the identification of neoplastic cells. Furthermore, in situ molecular techniques and PCR protocols have been introduced in the daily practice. This article provides an overview of the impact of immunophenotyping and immunogenotyping on the classification of lymphoid proliferations of B-cell lineage.
|Translated title of the contribution||Diagnostic significance of biopathological characterization of non-Hodgkin's lymphomas|
|Number of pages||8|
|Journal||Impegno Ospedaliero, Sezione Scientifica|
|Publication status||Published - 2001|
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