Diagnostic value of a lymphocyte stimulation test in cow milk protein intolerance

S. Albani, M. A. Avanzini, A. Plebani, M. S. Scotta, S. Perversi, G. Licardi, A. G. Ugazio, G. R. Burgio

Research output: Contribution to journalArticlepeer-review


In order to evaluate the diagnostic value of a lymphocyte stimulation test with casein and βlactoglobulin in cow milk intolerance (CMI), we studied 26 patients with a diagnosis of CMI and 25 age-matched controls with intestinal diseases other than CMI. Lymphocyte stimulation test to casein (P <.001) and βlactoglobulin (P <.001) was significantly higher among CMI patients. Seventeen patients were RAST positive and nine negative for whole milk proteins. No differences were found in the lymphocyte stimulation test response between RAST-positive and RAST-negative subjects. These results suggest that lymphocyte stimulation test with highly purified antigens in optimal concentrations is specific and could be useful in the diagnosis of CMI.

Original languageEnglish
Pages (from-to)489-492
Number of pages4
JournalAnnals of Allergy
Issue number6 I
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Immunology and Allergy


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