Diagnostic value of carbohydrate antigens in supernatants and sediments of pleural effusions

Daniela Terracciano, Claudia Mazzarella, Marcellino Cicalese, Sonia Galzerano, Gianfranco Apostolico, Angelina Di Carlo, Angela Mariano, Ciriaco Cecere, Vincenzo Macchia

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A panel of tumour markers including carcinoembryonic antigen (CEA), carbohydrate antigen (Ca)15-3, Ca125 and Ca19-9 were measured in the lysate of sediments and in the supernatants of pleural effusions of patients with benign and malignant disease. The tumour markers were also measured in the serum of the same patients. Of these patients, 32 had benign diseases (12 trasudative effusions associated with cirrhosis and 20 with non-malignant exudates: 12 pleuritis and 8 other inflammations) and 103 had malignant effusions (37 breast cancers, 29 lung cancers, 10 ovary cancers, 6 kidney cancers, 11 mesotheliomas and 10 lymphomas). We showed the highest level of CEA in pleural effusions of lung cancer followed by that in pleural effusions of breast cancer; whereas Ca15-3 was very high in the pleural effusions of breast and lung cancer. Concerning the lysate of sediment, CEA was high in the pleural effusions of patients with lung cancer and Ca15-3 in those of patients with breast cancer. The other markers are much less useful. For the remaining tumours, none of the markers tested appear to aid in the diagnosis of disease. In conclusion, our data suggest that the combined determination of tumour markers on supernatants and sediments of pleural effusion may provide additional information on the nature of pleural effusion, especially for cases with negative cytology.

Original languageEnglish
Pages (from-to)465-471
Number of pages7
JournalOncology Letters
Volume1
Issue number3
DOIs
Publication statusPublished - May 2010

Fingerprint

Pleural Effusion
Carbohydrates
Antigens
Lung Neoplasms
Tumor Biomarkers
Carcinoembryonic Antigen
Breast Neoplasms
Kidney Neoplasms
Ovarian Neoplasms
Pleurisy
Mesothelioma
Exudates and Transudates
Cell Biology
Lymphoma
Fibrosis
Inflammation
Serum

Keywords

  • Carbohydrate antigen 125
  • Carbohydrate antigen 15-3
  • Carcinoembryonic antigen
  • Pleural effusions

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Terracciano, D., Mazzarella, C., Cicalese, M., Galzerano, S., Apostolico, G., Di Carlo, A., ... Macchia, V. (2010). Diagnostic value of carbohydrate antigens in supernatants and sediments of pleural effusions. Oncology Letters, 1(3), 465-471. https://doi.org/10.3892/ol_00000082

Diagnostic value of carbohydrate antigens in supernatants and sediments of pleural effusions. / Terracciano, Daniela; Mazzarella, Claudia; Cicalese, Marcellino; Galzerano, Sonia; Apostolico, Gianfranco; Di Carlo, Angelina; Mariano, Angela; Cecere, Ciriaco; Macchia, Vincenzo.

In: Oncology Letters, Vol. 1, No. 3, 05.2010, p. 465-471.

Research output: Contribution to journalArticle

Terracciano, D, Mazzarella, C, Cicalese, M, Galzerano, S, Apostolico, G, Di Carlo, A, Mariano, A, Cecere, C & Macchia, V 2010, 'Diagnostic value of carbohydrate antigens in supernatants and sediments of pleural effusions', Oncology Letters, vol. 1, no. 3, pp. 465-471. https://doi.org/10.3892/ol_00000082
Terracciano D, Mazzarella C, Cicalese M, Galzerano S, Apostolico G, Di Carlo A et al. Diagnostic value of carbohydrate antigens in supernatants and sediments of pleural effusions. Oncology Letters. 2010 May;1(3):465-471. https://doi.org/10.3892/ol_00000082
Terracciano, Daniela ; Mazzarella, Claudia ; Cicalese, Marcellino ; Galzerano, Sonia ; Apostolico, Gianfranco ; Di Carlo, Angelina ; Mariano, Angela ; Cecere, Ciriaco ; Macchia, Vincenzo. / Diagnostic value of carbohydrate antigens in supernatants and sediments of pleural effusions. In: Oncology Letters. 2010 ; Vol. 1, No. 3. pp. 465-471.
@article{7ead9024e4844d45ba6b9066caf59423,
title = "Diagnostic value of carbohydrate antigens in supernatants and sediments of pleural effusions",
abstract = "A panel of tumour markers including carcinoembryonic antigen (CEA), carbohydrate antigen (Ca)15-3, Ca125 and Ca19-9 were measured in the lysate of sediments and in the supernatants of pleural effusions of patients with benign and malignant disease. The tumour markers were also measured in the serum of the same patients. Of these patients, 32 had benign diseases (12 trasudative effusions associated with cirrhosis and 20 with non-malignant exudates: 12 pleuritis and 8 other inflammations) and 103 had malignant effusions (37 breast cancers, 29 lung cancers, 10 ovary cancers, 6 kidney cancers, 11 mesotheliomas and 10 lymphomas). We showed the highest level of CEA in pleural effusions of lung cancer followed by that in pleural effusions of breast cancer; whereas Ca15-3 was very high in the pleural effusions of breast and lung cancer. Concerning the lysate of sediment, CEA was high in the pleural effusions of patients with lung cancer and Ca15-3 in those of patients with breast cancer. The other markers are much less useful. For the remaining tumours, none of the markers tested appear to aid in the diagnosis of disease. In conclusion, our data suggest that the combined determination of tumour markers on supernatants and sediments of pleural effusion may provide additional information on the nature of pleural effusion, especially for cases with negative cytology.",
keywords = "Carbohydrate antigen 125, Carbohydrate antigen 15-3, Carcinoembryonic antigen, Pleural effusions",
author = "Daniela Terracciano and Claudia Mazzarella and Marcellino Cicalese and Sonia Galzerano and Gianfranco Apostolico and {Di Carlo}, Angelina and Angela Mariano and Ciriaco Cecere and Vincenzo Macchia",
year = "2010",
month = "5",
doi = "10.3892/ol_00000082",
language = "English",
volume = "1",
pages = "465--471",
journal = "Oncology Letters",
issn = "1792-1074",
publisher = "Spandidos Publications",
number = "3",

}

TY - JOUR

T1 - Diagnostic value of carbohydrate antigens in supernatants and sediments of pleural effusions

AU - Terracciano, Daniela

AU - Mazzarella, Claudia

AU - Cicalese, Marcellino

AU - Galzerano, Sonia

AU - Apostolico, Gianfranco

AU - Di Carlo, Angelina

AU - Mariano, Angela

AU - Cecere, Ciriaco

AU - Macchia, Vincenzo

PY - 2010/5

Y1 - 2010/5

N2 - A panel of tumour markers including carcinoembryonic antigen (CEA), carbohydrate antigen (Ca)15-3, Ca125 and Ca19-9 were measured in the lysate of sediments and in the supernatants of pleural effusions of patients with benign and malignant disease. The tumour markers were also measured in the serum of the same patients. Of these patients, 32 had benign diseases (12 trasudative effusions associated with cirrhosis and 20 with non-malignant exudates: 12 pleuritis and 8 other inflammations) and 103 had malignant effusions (37 breast cancers, 29 lung cancers, 10 ovary cancers, 6 kidney cancers, 11 mesotheliomas and 10 lymphomas). We showed the highest level of CEA in pleural effusions of lung cancer followed by that in pleural effusions of breast cancer; whereas Ca15-3 was very high in the pleural effusions of breast and lung cancer. Concerning the lysate of sediment, CEA was high in the pleural effusions of patients with lung cancer and Ca15-3 in those of patients with breast cancer. The other markers are much less useful. For the remaining tumours, none of the markers tested appear to aid in the diagnosis of disease. In conclusion, our data suggest that the combined determination of tumour markers on supernatants and sediments of pleural effusion may provide additional information on the nature of pleural effusion, especially for cases with negative cytology.

AB - A panel of tumour markers including carcinoembryonic antigen (CEA), carbohydrate antigen (Ca)15-3, Ca125 and Ca19-9 were measured in the lysate of sediments and in the supernatants of pleural effusions of patients with benign and malignant disease. The tumour markers were also measured in the serum of the same patients. Of these patients, 32 had benign diseases (12 trasudative effusions associated with cirrhosis and 20 with non-malignant exudates: 12 pleuritis and 8 other inflammations) and 103 had malignant effusions (37 breast cancers, 29 lung cancers, 10 ovary cancers, 6 kidney cancers, 11 mesotheliomas and 10 lymphomas). We showed the highest level of CEA in pleural effusions of lung cancer followed by that in pleural effusions of breast cancer; whereas Ca15-3 was very high in the pleural effusions of breast and lung cancer. Concerning the lysate of sediment, CEA was high in the pleural effusions of patients with lung cancer and Ca15-3 in those of patients with breast cancer. The other markers are much less useful. For the remaining tumours, none of the markers tested appear to aid in the diagnosis of disease. In conclusion, our data suggest that the combined determination of tumour markers on supernatants and sediments of pleural effusion may provide additional information on the nature of pleural effusion, especially for cases with negative cytology.

KW - Carbohydrate antigen 125

KW - Carbohydrate antigen 15-3

KW - Carcinoembryonic antigen

KW - Pleural effusions

UR - http://www.scopus.com/inward/record.url?scp=77955752075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955752075&partnerID=8YFLogxK

U2 - 10.3892/ol_00000082

DO - 10.3892/ol_00000082

M3 - Article

AN - SCOPUS:77955752075

VL - 1

SP - 465

EP - 471

JO - Oncology Letters

JF - Oncology Letters

SN - 1792-1074

IS - 3

ER -