Abstract
Introduction: Vascularity influences the characteristics of gynecologic tumors observed with direct imaging techniques that reveal the macrovascular component of these lesions (color and power Doppler) and with indirect imaging involving the administration of contrast agents to examine the microcirculation and interstitial perfusion (contrast-enhanced computed tomography [CT] and magnetic resonance [MR] imaging). The purpose of this study was to determine whether contrast-enhanced ultrasonography (CEUS) of ovarian lesions provides useful information that cannot be obtained with conventional US. Materials and methods: We used CEUS to assess 72 nonspecific adnexal lesions in 61 patients. CEUS was performed with a 4.8-ml bolus of a second-generation ultrasonographic contrast agent and dedicated imaging algorithms. For each lesion, B-mode morphology, CEUS morphology, and time/intensity curves were evaluated. Results: In 8/61 cases (13.1%) CEUS offered no additional morphovascular information. In 38/61 cases (62.3%), it provided additional information that did not modify the management of the lesion, and in 15/61 cases (24.6%) it gave additional information that modified the management of the lesion. Malignant lesions were characterized by significantly shorter times to peak enhancement (11.9. ± 3.1 s vs 19.8. ± 4.0 s p<0.01) and significantly higher peak intensity (24.7. ± 4.2 dB vs 17.8. ± 3.3 dB p<0.01) compared with benign lesions. Conclusions: CEUS improves diagnostic confidence in the characterization of liquid-corpuscular lesions where conventional US is inconclusive. CEUS can be proposed as a valid alternative to CT and MR. However, information obtained by CEUS influences the therapy in a limited percentage of cases (24.6%).
| Original language | English |
|---|---|
| Pages (from-to) | 9-15 |
| Number of pages | 7 |
| Journal | Journal of Ultrasound |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Mar 2010 |
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Keywords
- Adnexal masses
- Contrast-enhanced ultrasound
- Ovarian cancer
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Internal Medicine
Cite this
Diagnostic value of contrast-enhanced ultrasonography in the characterization of ovarian tumors. / Sconfienza, L. M.; Perrone, N.; Delnevo, A.; Lacelli, F.; Murolo, C.; Gandolfo, N.; Serafini, G.
In: Journal of Ultrasound, Vol. 13, No. 1, 03.2010, p. 9-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diagnostic value of contrast-enhanced ultrasonography in the characterization of ovarian tumors
AU - Sconfienza, L. M.
AU - Perrone, N.
AU - Delnevo, A.
AU - Lacelli, F.
AU - Murolo, C.
AU - Gandolfo, N.
AU - Serafini, G.
PY - 2010/3
Y1 - 2010/3
N2 - Introduction: Vascularity influences the characteristics of gynecologic tumors observed with direct imaging techniques that reveal the macrovascular component of these lesions (color and power Doppler) and with indirect imaging involving the administration of contrast agents to examine the microcirculation and interstitial perfusion (contrast-enhanced computed tomography [CT] and magnetic resonance [MR] imaging). The purpose of this study was to determine whether contrast-enhanced ultrasonography (CEUS) of ovarian lesions provides useful information that cannot be obtained with conventional US. Materials and methods: We used CEUS to assess 72 nonspecific adnexal lesions in 61 patients. CEUS was performed with a 4.8-ml bolus of a second-generation ultrasonographic contrast agent and dedicated imaging algorithms. For each lesion, B-mode morphology, CEUS morphology, and time/intensity curves were evaluated. Results: In 8/61 cases (13.1%) CEUS offered no additional morphovascular information. In 38/61 cases (62.3%), it provided additional information that did not modify the management of the lesion, and in 15/61 cases (24.6%) it gave additional information that modified the management of the lesion. Malignant lesions were characterized by significantly shorter times to peak enhancement (11.9. ± 3.1 s vs 19.8. ± 4.0 s p<0.01) and significantly higher peak intensity (24.7. ± 4.2 dB vs 17.8. ± 3.3 dB p<0.01) compared with benign lesions. Conclusions: CEUS improves diagnostic confidence in the characterization of liquid-corpuscular lesions where conventional US is inconclusive. CEUS can be proposed as a valid alternative to CT and MR. However, information obtained by CEUS influences the therapy in a limited percentage of cases (24.6%).
AB - Introduction: Vascularity influences the characteristics of gynecologic tumors observed with direct imaging techniques that reveal the macrovascular component of these lesions (color and power Doppler) and with indirect imaging involving the administration of contrast agents to examine the microcirculation and interstitial perfusion (contrast-enhanced computed tomography [CT] and magnetic resonance [MR] imaging). The purpose of this study was to determine whether contrast-enhanced ultrasonography (CEUS) of ovarian lesions provides useful information that cannot be obtained with conventional US. Materials and methods: We used CEUS to assess 72 nonspecific adnexal lesions in 61 patients. CEUS was performed with a 4.8-ml bolus of a second-generation ultrasonographic contrast agent and dedicated imaging algorithms. For each lesion, B-mode morphology, CEUS morphology, and time/intensity curves were evaluated. Results: In 8/61 cases (13.1%) CEUS offered no additional morphovascular information. In 38/61 cases (62.3%), it provided additional information that did not modify the management of the lesion, and in 15/61 cases (24.6%) it gave additional information that modified the management of the lesion. Malignant lesions were characterized by significantly shorter times to peak enhancement (11.9. ± 3.1 s vs 19.8. ± 4.0 s p<0.01) and significantly higher peak intensity (24.7. ± 4.2 dB vs 17.8. ± 3.3 dB p<0.01) compared with benign lesions. Conclusions: CEUS improves diagnostic confidence in the characterization of liquid-corpuscular lesions where conventional US is inconclusive. CEUS can be proposed as a valid alternative to CT and MR. However, information obtained by CEUS influences the therapy in a limited percentage of cases (24.6%).
KW - Adnexal masses
KW - Contrast-enhanced ultrasound
KW - Ovarian cancer
UR - http://www.scopus.com/inward/record.url?scp=84655177785&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84655177785&partnerID=8YFLogxK
U2 - 10.1016/j.jus.2009.09.007
DO - 10.1016/j.jus.2009.09.007
M3 - Article
C2 - 23396092
AN - SCOPUS:84655177785
VL - 13
SP - 9
EP - 15
JO - Journal of Ultrasound
JF - Journal of Ultrasound
SN - 1971-3495
IS - 1
ER -