Diagnostic value of endomyocardial biopsy guided by electroanatomic voltage mapping in arrhythmogenic right ventricular cardiomyopathy/dysplasia

Andrea Avella, Giulia D'Amati, Augusto Pappalardo, Federica Re, Paola Francesca Silenzi, Francesco Laurenzi, Piergiuseppe De Girolamo, Gemma Pelargonio, Antonio Dello Russo, Pasquale Baratta, Giuseppe Messina, Paolo Zecchi, Elisabetta Zachara, Claudio Tondo

Research output: Contribution to journalArticle

Abstract

Voltage Mapping-Guided Biopsy in ARVC/D. Introduction: To improve the endomyocardial biopsy (EMB) diagnostic sensitivity for arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D), we hypothesized a biopsy sampling focused on selected right ventricle (RV) low-voltage areas identified by electroanatomic voltage mapping. Methods and Results: The study population (22 patients, 10 men; mean age 34 ± 10 years) included 11 patients with overt ARVC/D (group A) and 11 patients with suspected ARVC/D (group B), according to both arrhythmic profile and standardized noninvasive diagnostic criteria. In all 22 patients, an RV bipolar voltage mapping was performed with CARTO™ system sampling multiple endocardial sites (262 ± 61), during sinus rhythm, with a 0.5-1.5 mV color range setting of voltage display. All 11 (100%) group A patients and 8 of the 11 (73%) group B patients (P = nonsignificant [NS]) presented RV low-voltage areas (

Original languageEnglish
Pages (from-to)1127-1134
Number of pages8
JournalJournal of Cardiovascular Electrophysiology
Volume19
Issue number11
DOIs
Publication statusPublished - Nov 2008

Keywords

  • Arrhythmia
  • Biopsy
  • Cardiomyopathy
  • Mapping
  • Right ventricle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Avella, A., D'Amati, G., Pappalardo, A., Re, F., Silenzi, P. F., Laurenzi, F., De Girolamo, P., Pelargonio, G., Russo, A. D., Baratta, P., Messina, G., Zecchi, P., Zachara, E., & Tondo, C. (2008). Diagnostic value of endomyocardial biopsy guided by electroanatomic voltage mapping in arrhythmogenic right ventricular cardiomyopathy/dysplasia. Journal of Cardiovascular Electrophysiology, 19(11), 1127-1134. https://doi.org/10.1111/j.1540-8167.2008.01228.x