TY - JOUR
T1 - Diagnostic value of four assays for lipase determination in serum
T2 - A comparative reevaluation
AU - Panteghini, Mauro
AU - Pagani, Franca
AU - Bonora, Roberto
AU - Alebardi, Olga
AU - Ceriotti, Ferruccio
PY - 1991
Y1 - 1991
N2 - We assessed the diagnostic value of four commercially available methods for determining pancreatic lipase (LPS) in serum (the turbidimetric procedure from Boehringer, two enzymatic approaches from Kodak and Poli, and an immunochemical assay) in a population of 46 hospitalized patients with acute abdominal pain. In 31 cases (67.4%), the final diagnosis was acute pancreatitis. When evaluated by means of receiver-operating characteristic (ROC) curves, no significant differences were found among the procedures. Concerning clinical efficiency, all the assays had values equal to or greater than 90%. Using the calculation of the overlap index (OI) as a statistical approach to quantify the clinical utility of various LPS assays, the test having the greatest potential for differentiating between patients with and without acute pancreatitis was the turbidimetric assay (OI = 0.14).
AB - We assessed the diagnostic value of four commercially available methods for determining pancreatic lipase (LPS) in serum (the turbidimetric procedure from Boehringer, two enzymatic approaches from Kodak and Poli, and an immunochemical assay) in a population of 46 hospitalized patients with acute abdominal pain. In 31 cases (67.4%), the final diagnosis was acute pancreatitis. When evaluated by means of receiver-operating characteristic (ROC) curves, no significant differences were found among the procedures. Concerning clinical efficiency, all the assays had values equal to or greater than 90%. Using the calculation of the overlap index (OI) as a statistical approach to quantify the clinical utility of various LPS assays, the test having the greatest potential for differentiating between patients with and without acute pancreatitis was the turbidimetric assay (OI = 0.14).
KW - acute abdominal pain
KW - acute pancreatitis
KW - decision-threshold values
KW - diagnostic efficiency
KW - emergency procedure
KW - pancreatic lipase
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U2 - 10.1016/S0009-9120(05)80009-8
DO - 10.1016/S0009-9120(05)80009-8
M3 - Article
C2 - 1773490
AN - SCOPUS:0026352525
VL - 24
SP - 497
EP - 503
JO - Clinical Biochemistry
JF - Clinical Biochemistry
SN - 0009-9120
IS - 6
ER -