TY - JOUR
T1 - Diagnostic value of PRND gene expression profiles in astrocytomas
T2 - Relationship to tumor grades of malignancy
AU - Comincini, Sergio
AU - Ferrara, V.
AU - Arias, A.
AU - Malovini, A.
AU - Azzalin, A.
AU - Ferretti, L.
AU - Benericetti, E.
AU - Cardarelli, M.
AU - Gerosa, M.
AU - Passarin, M. G.
AU - Turazzi, S.
AU - Bellazzi, R.
PY - 2007/5
Y1 - 2007/5
N2 - Doppel (PRND) is a paralogue of the mammalian prion (PRNP) gene. It is abundant in testis and, unlike PRNP, it is expressed at low levels in the adult central nervous system (CNS). Besides, doppel overexpression correlates with some prion-disease pathological features, such as ataxia and death of cerebellar neurons. Recently, ectopic expression of doppel was found in two different tumor types, specifically in glial and haematological cancers. In order to address clinical important issues, PRND mRNA expression was investigated in a panel of 111 astrocytoma tissue samples, histologically classified according to the World Health Organization (WHO) criteria (6 grade I pilocytic astrocytomas, 15 grade II low-grade astrocytomas, 26 grade III anaplastic astrocytomas and 64 grade IV glioblastoma multiforme). Real-time PRND gene expression profiling, after normalisation with GAPDH, revealed large differences between low (WHO I and II) and high grade (III and IV) of malignancy (P
AB - Doppel (PRND) is a paralogue of the mammalian prion (PRNP) gene. It is abundant in testis and, unlike PRNP, it is expressed at low levels in the adult central nervous system (CNS). Besides, doppel overexpression correlates with some prion-disease pathological features, such as ataxia and death of cerebellar neurons. Recently, ectopic expression of doppel was found in two different tumor types, specifically in glial and haematological cancers. In order to address clinical important issues, PRND mRNA expression was investigated in a panel of 111 astrocytoma tissue samples, histologically classified according to the World Health Organization (WHO) criteria (6 grade I pilocytic astrocytomas, 15 grade II low-grade astrocytomas, 26 grade III anaplastic astrocytomas and 64 grade IV glioblastoma multiforme). Real-time PRND gene expression profiling, after normalisation with GAPDH, revealed large differences between low (WHO I and II) and high grade (III and IV) of malignancy (P
KW - Astrocytoma
KW - Gene expression
KW - Molecular diagnosis
KW - Real-time PCR analysis
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M3 - Article
C2 - 17390034
AN - SCOPUS:34548583594
VL - 17
SP - 989
EP - 996
JO - Oncology Reports
JF - Oncology Reports
SN - 1021-335X
IS - 5
ER -