Diagnostic value of serum cholylglycine radioimmunoassay in chronic asymptomatic HBsAg carriers

Roberto De Franchis, Maurizio Vecchi, Massimo Primignani, Claudio Bonato, Anna Parravicini, Rita Cambieri, Danilo Ciaci, Giorgio Annoni

Research output: Contribution to journalArticlepeer-review

Abstract

The correlation between histological liver abnormalities and fasting serum cholylglycine levels was investigated in 75 chronic asymptomatic HBsAg carriers with normal conventional liver tests, to clarify whether serum CG radioimmunoassay could help in distinguishing the carriers with histological liver damage from those with normal histological findings. Mean (±SEM) fasting serum CG levels were 11.6±1.5 μg/dl in 56 carriers with normal liver histology, 14.6±4.2 μg/dl in 16 subjects with CPH and 95.6±54 μg/dl in three carriers with CAH. The incidence of abnormal values (>40 μg/dl) among carriers with CAH (66%) was significantly higher than in the other two groups (1.8 and 12.5%, respectively). It is concluded that, among chronic asymptomatic HBsAg carriers with normal conventional liver tests, those who show abnormal serum CG levels are likely to have severe histological damage. This justifies the inclusion of CG radioimmunoassay in the routine follow-up of these subjects. The occurrence of false-positive and false-negative results must be considered if the test is used as an aid in the selection of patients for liver biopsy.

Original languageEnglish
Pages (from-to)301-305
Number of pages5
JournalLa Ricerca in Clinica e in Laboratorio
Volume13
Issue number3
DOIs
Publication statusPublished - Jul 1983

Keywords

  • Asymptomatic carriers
  • Chronic hepatitis
  • Hepatitis B surface antigen
  • Liver biopsy
  • Serum cholylglycine radioimmunoassay

ASJC Scopus subject areas

  • Clinical Biochemistry

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