Diagnostic value of serum immunoreactive conjugated cholic or chenodeoxycholic acids in detecting hepatobiliary diseases - Comparison with levels of 3α-hydroxy bile acids determined enzymatically and with routine liver tests

Roberto Ferraris, M. Tilde Fiorentini, Giovanni Galatola, Piera Rolfo, Marco De La Pierre

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The diagnostic value of the enzymatic fluorometric method for total serum bile acids (TSBA) and for radioimmunoassay measurement for conjugated cholic acid (CCA) or chenodeoxycholic acid was compared with that of routine liver function tests in 223 patients with liver disease, 88 healthy subjects, and 118 patients affected by other diseases. The value of the tests for screening in the general population was assessed by simulation, using estimates of disease prevalence. TSBA was significantly more sensitive (78%) but less specific (94%) than CCA (sensitivity of 69%, specificity of 98%). Aspartate aminotransferase was nearly as sensitive (74%) as TSBA, but significantly less specific (93%) than CCA. CCA provided the highest positive predictivity (98%), even in a screening simulation (32%). With the use of sequential aspartate aminotransferase measurement followed by CCA, this value rose to 100%. This test procedure appears to be the best screening method for liver diseases available at present.

Original languageEnglish
Pages (from-to)817-823
Number of pages7
JournalDigestive Diseases and Sciences
Volume32
Issue number8
DOIs
Publication statusPublished - Aug 1987

Fingerprint

Chenodeoxycholic Acid
Cholic Acid
Hydroxy Acids
Bile Acids and Salts
Liver
Serum
Aspartate Aminotransferases
Liver Diseases
Liver Function Tests
Radioimmunoassay
Healthy Volunteers
Sensitivity and Specificity
Population

Keywords

  • bile acid
  • diagnostic use
  • liver diseases
  • liver function tests
  • radioimmunoassay
  • screening process
  • serum bile acids

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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title = "Diagnostic value of serum immunoreactive conjugated cholic or chenodeoxycholic acids in detecting hepatobiliary diseases - Comparison with levels of 3α-hydroxy bile acids determined enzymatically and with routine liver tests",
abstract = "The diagnostic value of the enzymatic fluorometric method for total serum bile acids (TSBA) and for radioimmunoassay measurement for conjugated cholic acid (CCA) or chenodeoxycholic acid was compared with that of routine liver function tests in 223 patients with liver disease, 88 healthy subjects, and 118 patients affected by other diseases. The value of the tests for screening in the general population was assessed by simulation, using estimates of disease prevalence. TSBA was significantly more sensitive (78{\%}) but less specific (94{\%}) than CCA (sensitivity of 69{\%}, specificity of 98{\%}). Aspartate aminotransferase was nearly as sensitive (74{\%}) as TSBA, but significantly less specific (93{\%}) than CCA. CCA provided the highest positive predictivity (98{\%}), even in a screening simulation (32{\%}). With the use of sequential aspartate aminotransferase measurement followed by CCA, this value rose to 100{\%}. This test procedure appears to be the best screening method for liver diseases available at present.",
keywords = "bile acid, diagnostic use, liver diseases, liver function tests, radioimmunoassay, screening process, serum bile acids",
author = "Roberto Ferraris and {Tilde Fiorentini}, M. and Giovanni Galatola and Piera Rolfo and {De La Pierre}, Marco",
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AU - Ferraris, Roberto

AU - Tilde Fiorentini, M.

AU - Galatola, Giovanni

AU - Rolfo, Piera

AU - De La Pierre, Marco

PY - 1987/8

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N2 - The diagnostic value of the enzymatic fluorometric method for total serum bile acids (TSBA) and for radioimmunoassay measurement for conjugated cholic acid (CCA) or chenodeoxycholic acid was compared with that of routine liver function tests in 223 patients with liver disease, 88 healthy subjects, and 118 patients affected by other diseases. The value of the tests for screening in the general population was assessed by simulation, using estimates of disease prevalence. TSBA was significantly more sensitive (78%) but less specific (94%) than CCA (sensitivity of 69%, specificity of 98%). Aspartate aminotransferase was nearly as sensitive (74%) as TSBA, but significantly less specific (93%) than CCA. CCA provided the highest positive predictivity (98%), even in a screening simulation (32%). With the use of sequential aspartate aminotransferase measurement followed by CCA, this value rose to 100%. This test procedure appears to be the best screening method for liver diseases available at present.

AB - The diagnostic value of the enzymatic fluorometric method for total serum bile acids (TSBA) and for radioimmunoassay measurement for conjugated cholic acid (CCA) or chenodeoxycholic acid was compared with that of routine liver function tests in 223 patients with liver disease, 88 healthy subjects, and 118 patients affected by other diseases. The value of the tests for screening in the general population was assessed by simulation, using estimates of disease prevalence. TSBA was significantly more sensitive (78%) but less specific (94%) than CCA (sensitivity of 69%, specificity of 98%). Aspartate aminotransferase was nearly as sensitive (74%) as TSBA, but significantly less specific (93%) than CCA. CCA provided the highest positive predictivity (98%), even in a screening simulation (32%). With the use of sequential aspartate aminotransferase measurement followed by CCA, this value rose to 100%. This test procedure appears to be the best screening method for liver diseases available at present.

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KW - diagnostic use

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KW - liver function tests

KW - radioimmunoassay

KW - screening process

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