Diagnostic value of soluble CD14 subtype (sCD14-ST) presepsin for the postmortem diagnosis of sepsis-related fatalities

Cristian Palmiere, Michele Mussap, Daniel Bardy, Francesco Cibecchini, Patrice Mangin

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The first aim of this study was to assess the diagnostic performance of presepsin (sCD14-ST) in postmortem serum from femoral blood compared to procalcitonin (PCT) to detect sepsis-related fatalities. The second aim was to compare sCD14-ST levels found in postmortem serum to the values in pericardial fluid to investigate the usefulness of the latter as an alternative biological fluid. Two study groups were formed, a sepsis-related fatalities group and a control group. Radiology (unenhanced CT scans and postmortem angiographies), autopsies, histology, neuropathology, and toxicology as well as other postmortem biochemistry investigations were performed in all cases. Microbiological investigations on right cardiac blood were carried out exclusively in septic cases. The results of this study indicated that postmortem serum PCT and sCD14-ST levels, individually considered, allowed septic cases to be identified. Even though increases in both PCT and sCD14-ST concentrations were observed in the control cases, coherent PCT and sCD14-ST results in cases with suspected sepsis allowed the diagnosis to be confirmed. Conversely, no relevant correlation was identified between postmortem serum and pericardial fluid sCD14-ST levels in either the septic or control groups.

Original languageEnglish
Pages (from-to)799-808
Number of pages10
JournalInternational Journal of Legal Medicine
Volume127
Issue number4
DOIs
Publication statusPublished - Jul 2013

Fingerprint

Calcitonin
Sepsis
Serum
Control Groups
Thigh
Radiology
Biochemistry
Toxicology
Autopsy
Histology
Angiography
Pericardial Fluid

Keywords

  • Postmortem biochemistry
  • Presepsin
  • Procalcitonin
  • Sepsis
  • Soluble CD14 subtype

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Diagnostic value of soluble CD14 subtype (sCD14-ST) presepsin for the postmortem diagnosis of sepsis-related fatalities. / Palmiere, Cristian; Mussap, Michele; Bardy, Daniel; Cibecchini, Francesco; Mangin, Patrice.

In: International Journal of Legal Medicine, Vol. 127, No. 4, 07.2013, p. 799-808.

Research output: Contribution to journalArticle

Palmiere, Cristian ; Mussap, Michele ; Bardy, Daniel ; Cibecchini, Francesco ; Mangin, Patrice. / Diagnostic value of soluble CD14 subtype (sCD14-ST) presepsin for the postmortem diagnosis of sepsis-related fatalities. In: International Journal of Legal Medicine. 2013 ; Vol. 127, No. 4. pp. 799-808.
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