Abstract
The first aim of this study was to assess the diagnostic performance of presepsin (sCD14-ST) in postmortem serum from femoral blood compared to procalcitonin (PCT) to detect sepsis-related fatalities. The second aim was to compare sCD14-ST levels found in postmortem serum to the values in pericardial fluid to investigate the usefulness of the latter as an alternative biological fluid. Two study groups were formed, a sepsis-related fatalities group and a control group. Radiology (unenhanced CT scans and postmortem angiographies), autopsies, histology, neuropathology, and toxicology as well as other postmortem biochemistry investigations were performed in all cases. Microbiological investigations on right cardiac blood were carried out exclusively in septic cases. The results of this study indicated that postmortem serum PCT and sCD14-ST levels, individually considered, allowed septic cases to be identified. Even though increases in both PCT and sCD14-ST concentrations were observed in the control cases, coherent PCT and sCD14-ST results in cases with suspected sepsis allowed the diagnosis to be confirmed. Conversely, no relevant correlation was identified between postmortem serum and pericardial fluid sCD14-ST levels in either the septic or control groups.
| Original language | English |
|---|---|
| Pages (from-to) | 799-808 |
| Number of pages | 10 |
| Journal | International Journal of Legal Medicine |
| Volume | 127 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2013 |
Fingerprint
Keywords
- Postmortem biochemistry
- Presepsin
- Procalcitonin
- Sepsis
- Soluble CD14 subtype
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medicine(all)
Cite this
Diagnostic value of soluble CD14 subtype (sCD14-ST) presepsin for the postmortem diagnosis of sepsis-related fatalities. / Palmiere, Cristian; Mussap, Michele; Bardy, Daniel; Cibecchini, Francesco; Mangin, Patrice.
In: International Journal of Legal Medicine, Vol. 127, No. 4, 07.2013, p. 799-808.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diagnostic value of soluble CD14 subtype (sCD14-ST) presepsin for the postmortem diagnosis of sepsis-related fatalities
AU - Palmiere, Cristian
AU - Mussap, Michele
AU - Bardy, Daniel
AU - Cibecchini, Francesco
AU - Mangin, Patrice
PY - 2013/7
Y1 - 2013/7
N2 - The first aim of this study was to assess the diagnostic performance of presepsin (sCD14-ST) in postmortem serum from femoral blood compared to procalcitonin (PCT) to detect sepsis-related fatalities. The second aim was to compare sCD14-ST levels found in postmortem serum to the values in pericardial fluid to investigate the usefulness of the latter as an alternative biological fluid. Two study groups were formed, a sepsis-related fatalities group and a control group. Radiology (unenhanced CT scans and postmortem angiographies), autopsies, histology, neuropathology, and toxicology as well as other postmortem biochemistry investigations were performed in all cases. Microbiological investigations on right cardiac blood were carried out exclusively in septic cases. The results of this study indicated that postmortem serum PCT and sCD14-ST levels, individually considered, allowed septic cases to be identified. Even though increases in both PCT and sCD14-ST concentrations were observed in the control cases, coherent PCT and sCD14-ST results in cases with suspected sepsis allowed the diagnosis to be confirmed. Conversely, no relevant correlation was identified between postmortem serum and pericardial fluid sCD14-ST levels in either the septic or control groups.
AB - The first aim of this study was to assess the diagnostic performance of presepsin (sCD14-ST) in postmortem serum from femoral blood compared to procalcitonin (PCT) to detect sepsis-related fatalities. The second aim was to compare sCD14-ST levels found in postmortem serum to the values in pericardial fluid to investigate the usefulness of the latter as an alternative biological fluid. Two study groups were formed, a sepsis-related fatalities group and a control group. Radiology (unenhanced CT scans and postmortem angiographies), autopsies, histology, neuropathology, and toxicology as well as other postmortem biochemistry investigations were performed in all cases. Microbiological investigations on right cardiac blood were carried out exclusively in septic cases. The results of this study indicated that postmortem serum PCT and sCD14-ST levels, individually considered, allowed septic cases to be identified. Even though increases in both PCT and sCD14-ST concentrations were observed in the control cases, coherent PCT and sCD14-ST results in cases with suspected sepsis allowed the diagnosis to be confirmed. Conversely, no relevant correlation was identified between postmortem serum and pericardial fluid sCD14-ST levels in either the septic or control groups.
KW - Postmortem biochemistry
KW - Presepsin
KW - Procalcitonin
KW - Sepsis
KW - Soluble CD14 subtype
UR - http://www.scopus.com/inward/record.url?scp=84879884785&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879884785&partnerID=8YFLogxK
U2 - 10.1007/s00414-012-0804-5
DO - 10.1007/s00414-012-0804-5
M3 - Article
C2 - 23263410
AN - SCOPUS:84879884785
VL - 127
SP - 799
EP - 808
JO - International Journal of Legal Medicine
JF - International Journal of Legal Medicine
SN - 0937-9827
IS - 4
ER -