Diagnostic work-up of inflammatory bowel disease in children: The role of calprotectin assay

A. Diamanti, F. Panetta, M. S. Basso, A. Forgione, F. Colistro, F. Bracci, B. Papadatou, P. Francalanci, F. Torroni, D. Knafelz, F. Fina, M. Castro

Research output: Contribution to journalArticle

Abstract

Background: Some reports highlight the potential application of fecal calprotectin as a direct biomarker of intestinal inflammation and, therefore, as support in choosing candidates for endoscopy. The value of 100 μg/g was recently assumed as the best cutoff for this assay. The purpose of this study was to assess the diagnostic precision of the fecal calprotectin assay, compared to histology, as a stool-screening biomarker for inflammatory bowel disease (IBD) among a group of prospectively identified patients referred for recurrent abdominal pain and altered bowel habits. Methods: Between 1999 and 2007 we prospectively evaluated the calprotectin assay in a cohort of patients with recurrent abdominal pain and altered bowel habits associated or not with other symptoms suggestive of IBD. All patients suspected of IBD, according to Rome and Porto criteria, provided stool specimens for the calprotectin assay and subsequently underwent endoscopic procedures. Results: Compared to histology, the cutoff of 100 μg/g reached a sensitivity and specificity of 100% and 68%, respectively, and a likelihood ratio (LR) of 3.1. The cutoff value of 160 μg/g, however, in our series produced the best joint estimate of sensitivity and specificity: 100% and 80%, respectively, with an LR of 5. Conclusions: In pediatric patients with recurrent abdominal pain and changes in stool habits, a positive calprotectin assay is closely associated with IBD; its systematic employment, therefore, seems to improve the process of endoscopy referral. This test, simple and inexpensive, could be included in the first noninvasive phase of an IBD diagnostic work-up. (Inflamm Bowel Dis 2010)

Original languageEnglish
Pages (from-to)1926-1930
Number of pages5
JournalInflammatory Bowel Diseases
Volume16
Issue number11
DOIs
Publication statusPublished - Nov 2010

Keywords

  • fecal calprotectin
  • inflammatory bowel disease
  • pediatric patients

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

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    Diamanti, A., Panetta, F., Basso, M. S., Forgione, A., Colistro, F., Bracci, F., Papadatou, B., Francalanci, P., Torroni, F., Knafelz, D., Fina, F., & Castro, M. (2010). Diagnostic work-up of inflammatory bowel disease in children: The role of calprotectin assay. Inflammatory Bowel Diseases, 16(11), 1926-1930. https://doi.org/10.1002/ibd.21257