Diaspirin cross-linked hemoglobin and blood substitutes

Stefano Romagnoli, Giovanni Zagli, Zaccaria Ricci

Research output: Chapter in Book/Report/Conference proceedingChapter


Diaspirin cross-linked hemoglobin is a hemoglobin-based oxygen carrier. Compared to red blood cells, diaspirin cross-linked hemoglobin, as oxygen carriers in general, has a reduced risk of transfusion harming effects, universal compatibility, infinite availability and long-term storage capability. Despite initial enthusiasm, the trial by Sloan and colleagues showed an increased risk of death in patients treated with this blood substitute on the top of standard fluid resuscitation in hemorrhagic trauma patients. These results led to the withdrawal of the drug from the market. Several other substitutes were tested, but none showed adequate results. Hemopure®, glutaraldehyde polymerized bovine hemoglobin, is the only oxygen carrier available on the market in South Africa and Russia. At the moment, new and safer alternative products are needed before transfusion medicine can be profoundly modified.

Original languageEnglish
Title of host publicationReducing Mortality in Critically Ill Patients
PublisherSpringer International Publishing
Number of pages9
ISBN (Print)9783319175157, 9783319175140
Publication statusPublished - Jan 1 2015


  • Cardiac surgery
  • Mortality
  • Orthopedic surgery
  • Oxygen carriers
  • Trauma

ASJC Scopus subject areas

  • Medicine(all)


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