TY - JOUR
T1 - Diastolic dysfunction diagnosed by tissue Doppler imaging in cirrhotic patients
T2 - Prevalence and its possible relationship with clinical outcome
AU - Falletta, Calogero
AU - Filì, Daniela
AU - Nugara, Cinzia
AU - Di Gesaro, Gabriele
AU - Minà, Chiara
AU - Baravoglia, Cesar Mario Hernandez
AU - Romano, Giuseppe
AU - Scardulla, Cesare
AU - Tuzzolino, Fabio
AU - Vizzini, Giovanni
AU - Clemenza, Francesco
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Background Cirrhotic cardiomyopathy has been characterized by impaired contractile response to stress and/or altered diastolic relaxation, with electrophysiological abnormalities in the absence of known cardiac disease. However, the clinical significance of diastolic dysfunction (DDF) in cirrhotic patients has not been clarified. Methods We studied 84 cirrhotic patients with normal systolic function to evaluate the prevalence of DDF using tissue Doppler imaging, and to investigate the possible correlation of DDF with outcomes (hospitalization, death) and with the specific causes of death. Results The mean follow-up was 10 ± 8 months. DDF was diagnosed in 22 patients (26.2%). Patients with DDF more frequently had ascites (90.9% vs. 64.5 %; p = 0.026), lower levels of albumin (OR: 5.39; p = 0.004), higher NT-proBNP levels, and longer QTc interval (464 ± 23 ms vs. 452 ± 30 ms; p = 0.039). At follow-up, patients with DDF did not have a higher incidence of adverse events in terms of hospitalization and death. Conclusions The presence of diastolic dysfunction has not been found to be clearly associated with outcome, and prognosis has been determined primarily by the severity of liver disease.
AB - Background Cirrhotic cardiomyopathy has been characterized by impaired contractile response to stress and/or altered diastolic relaxation, with electrophysiological abnormalities in the absence of known cardiac disease. However, the clinical significance of diastolic dysfunction (DDF) in cirrhotic patients has not been clarified. Methods We studied 84 cirrhotic patients with normal systolic function to evaluate the prevalence of DDF using tissue Doppler imaging, and to investigate the possible correlation of DDF with outcomes (hospitalization, death) and with the specific causes of death. Results The mean follow-up was 10 ± 8 months. DDF was diagnosed in 22 patients (26.2%). Patients with DDF more frequently had ascites (90.9% vs. 64.5 %; p = 0.026), lower levels of albumin (OR: 5.39; p = 0.004), higher NT-proBNP levels, and longer QTc interval (464 ± 23 ms vs. 452 ± 30 ms; p = 0.039). At follow-up, patients with DDF did not have a higher incidence of adverse events in terms of hospitalization and death. Conclusions The presence of diastolic dysfunction has not been found to be clearly associated with outcome, and prognosis has been determined primarily by the severity of liver disease.
KW - Cirrhosis
KW - Diastolic dysfunction
KW - Tissue Doppler imaging
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U2 - 10.1016/j.ejim.2015.10.009
DO - 10.1016/j.ejim.2015.10.009
M3 - Article
C2 - 26525531
AN - SCOPUS:84950320228
VL - 26
SP - 830
EP - 834
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
SN - 0953-6205
IS - 10
ER -