Diastolic function in acute myocardial infarction: A radionuclide study

D. Bonaduce, G. Morgano, M. Petretta, P. Arrichiello, G. Conforti, S. Betocchi, M. Salvatore, M. Chiariello

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We studied left ventricular diastolic function by equilibrium gated radionuclide angiography in patients as follows: 75 with acute myocardial infarction (AMI), 35 with anterior or anteroseptal necrosis (Group A) and 40 with inferior, inferolateral, or posterior necrosis (Group I). The ejection fraction (EF) was lower in Group A than Group I (41.9 ± 2.5 vs. 57.1 ± 2.0%, p <0.001), as was peak diastolic filling rate normalized to end diastolic volume (PDFR-EDV/sec) (1.9 ± 0.1 vs. 2.4 ± 0.1 EDV/sec, p <0.05). PDFR normalized to stroke volume was similar in both groups. An excellent linear correlation was found between EF and PDFR-EDV/sec in the total study population. Isovolumic relaxation period (IRP) was beyond our upper normal value of 94 msec in 64% of patients and it was shorter in Group A than I (95.8 ± 12.7 vs. 147.0 ± 13.6 msec, p <0.05). The presence of shorter IRP in Group A than in I is probably a result of an earlier mitral valve opening as a consequence of higher left atrial pressure.

Original languageEnglish
Pages (from-to)1786-1789
Number of pages4
JournalJournal of Nuclear Medicine
Issue number11
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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