TY - JOUR
T1 - Dielectric Properties Characterization From 0.5 to 50 GHz of Breast Cancer Tissues
AU - Martellosio, Andrea
AU - Pasian, Marco
AU - Bozzi, Maurizio
AU - Perregrini, Luca
AU - Mazzanti, Andrea
AU - Svelto, Francesco
AU - Summers, Paul Eugene
AU - Renne, Giuseppe
AU - Preda, Lorenzo
AU - Bellomi, Massimo
PY - 2016/12/12
Y1 - 2016/12/12
N2 - Knowledge of the dielectric properties of human tissues is important for several biomedical applications, including imaging and hyperthermia treatment, as well as for determining safety thresholds in policy making. Breast tissues, both normal and tumorous, are of particular interest because of the medical and social impact of breast cancers. While experimental data is available up to 20 GHz, for higher frequencies, this information is missing, or has been extrapolated from models based on lower-frequency data. Emerging technologies and applications in the millimeter-wave region would benefit from experimental data that bridge this gap. This paper presents the characterization of dielectric properties of breast tissues for the frequency range from 0.5 to 50 GHz. Cole-Cole models are derived for normal and tumorous tissues based on experimental measurements on more than 220 tissue samples obtained at surgery (ex vivo) from a population exceeding 50 patients, covering a wide span of normal and tumorous tissues, from patients ranging in age from 28 to 85 years, with a time from excision to measurements under 3.5 h. This paper also presents a comprehensive analysis of the differences between normal and tumorous breast tissues at different frequencies in terms of sensitivity and specificity.
AB - Knowledge of the dielectric properties of human tissues is important for several biomedical applications, including imaging and hyperthermia treatment, as well as for determining safety thresholds in policy making. Breast tissues, both normal and tumorous, are of particular interest because of the medical and social impact of breast cancers. While experimental data is available up to 20 GHz, for higher frequencies, this information is missing, or has been extrapolated from models based on lower-frequency data. Emerging technologies and applications in the millimeter-wave region would benefit from experimental data that bridge this gap. This paper presents the characterization of dielectric properties of breast tissues for the frequency range from 0.5 to 50 GHz. Cole-Cole models are derived for normal and tumorous tissues based on experimental measurements on more than 220 tissue samples obtained at surgery (ex vivo) from a population exceeding 50 patients, covering a wide span of normal and tumorous tissues, from patients ranging in age from 28 to 85 years, with a time from excision to measurements under 3.5 h. This paper also presents a comprehensive analysis of the differences between normal and tumorous breast tissues at different frequencies in terms of sensitivity and specificity.
UR - http://www.scopus.com/inward/record.url?scp=85006958186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006958186&partnerID=8YFLogxK
U2 - 10.1109/TMTT.2016.2631162
DO - 10.1109/TMTT.2016.2631162
M3 - Article
AN - SCOPUS:85006958186
JO - IEEE Transactions on Microwave Theory and Techniques
JF - IEEE Transactions on Microwave Theory and Techniques
SN - 0018-9480
ER -