TY - JOUR
T1 - Dienogest in the treatment of endometriosis
AU - Bizzarri, Nicolò
AU - Remorgida, Valentino
AU - Leone Roberti Maggiore, Umberto
AU - Scala, Carolina
AU - Tafi, Emanuela
AU - Ghirardi, Valentina
AU - Salvatore, Stefano
AU - Candiani, Massimo
AU - Venturini, Pier Luigi
AU - Ferrero, Simone
PY - 2014
Y1 - 2014
N2 - Introduction: Dienogest (DNG) is an oral progestin, derivative of 19-nortestosterone, that has recently been introduced for the treatment of endometriosis.Areas covered: This review examines the clinical efficacy, safety and tolerability of DNG in the treatment of endometriosis. The material included in the current manuscript was searched and obtained via Medline, Pubmed and EMBASE, from inception until February 2014. The term 'dienogest' was associated with the following search terms: 'endometriosis', 'pharmacokinetics', 'safety' and 'efficacy'.Expert opinion: Several trials demonstrated the clinical efficacy, safety and tolerability of DNG. However the use of DNG is associated with some limitations. So far, no study investigated the potential of contraceptive effect of this treatment and therefore, it should be recommended with other methods of contraception (e.g., barrier methods). A further limitation of the use of DNG as daily therapy in the long term is that the cost of the therapy is higher than other progestins available on the market and combined oral contraceptives. Therefore, future studies should be designed to compare the efficacy and safety of DNG with other progestins.
AB - Introduction: Dienogest (DNG) is an oral progestin, derivative of 19-nortestosterone, that has recently been introduced for the treatment of endometriosis.Areas covered: This review examines the clinical efficacy, safety and tolerability of DNG in the treatment of endometriosis. The material included in the current manuscript was searched and obtained via Medline, Pubmed and EMBASE, from inception until February 2014. The term 'dienogest' was associated with the following search terms: 'endometriosis', 'pharmacokinetics', 'safety' and 'efficacy'.Expert opinion: Several trials demonstrated the clinical efficacy, safety and tolerability of DNG. However the use of DNG is associated with some limitations. So far, no study investigated the potential of contraceptive effect of this treatment and therefore, it should be recommended with other methods of contraception (e.g., barrier methods). A further limitation of the use of DNG as daily therapy in the long term is that the cost of the therapy is higher than other progestins available on the market and combined oral contraceptives. Therefore, future studies should be designed to compare the efficacy and safety of DNG with other progestins.
KW - Dienogest
KW - Efficacy
KW - Endometriosis
KW - Hormonal
KW - Pharmacokinetics
KW - Progestin
KW - Safety
UR - http://www.scopus.com/inward/record.url?scp=84905869200&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905869200&partnerID=8YFLogxK
U2 - 10.1517/14656566.2014.943734
DO - 10.1517/14656566.2014.943734
M3 - Article
C2 - 25069386
AN - SCOPUS:84905869200
VL - 15
SP - 1889
EP - 1902
JO - Expert Opinion on Pharmacotherapy
JF - Expert Opinion on Pharmacotherapy
SN - 1465-6566
IS - 13
ER -