Dienogest treatment improves quality of life in women with endometriosis

Stefano Luisi, Fabio Parazzini, Stefano Angioni, Saverio Arena, Paolo Berretta, Massimo Candiani, Vito Cela, Luigi Fedele, Pietro Litta, Antonio Maiorana, Luigi Nappi, Maria Grazia Porpora, Maurizio Rosati, Fulvio Zullo, Claudia Tosti, Felice Petraglia

Research output: Contribution to journalArticlepeer-review


Background: The aim of this study was to assess the efficacy of dienogest treatment in improving quality of life in women with endometriosis. Methods: This was a prospective observational multicenter study at the universities of Siena, Milano, Cagliari, Perugia, Busto Arstizio, Pisa, Padova, Palermo, Foggia, Roma, Pescara and Catanzaro, including 142 patients with a diagnosis of endometriosis who received dienogest 2 mg once daily, for up to 90 days. Each patient underwent an evaluation of pelvic pain measured by visual analogue scale (VAS) from 0 to 10 points, and of quality of life measured by a mental and physical index before and after treatment. Results: The mean ± SD of VAS was 8.2 ± 1.6 in women with endometriosis, and this progressively and signifi- cantly decreased to 5.9 ± 2.6 at the end of the study. Mental index score values increased from 39.0 ± 9.8 to 46.0 ± 9.1 (p

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalJournal of Endometriosis and Pelvic Pain Disorders
Issue number4
Publication statusPublished - 2015


  • Dienogest
  • Endometriosis
  • Pelvic pain
  • Quality of life
  • Stress

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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