Diet and hip fractures among elderly Europeans in the EPIC cohort

V. Benetou, P. Orfanos, D. Zylis, S. Sieri, P. Contiero, R. Tumino, M. C. Giurdanella, P. H M Peeters, J. Linseisen, A. Nieters, H. Boeing, C. Weikert, U. Pettersson, I. Johansson, H. B. Bueno-De-Mesquita, M. Dorronsoro, P. Boffetta, A. Trichopoulou

Research output: Contribution to journalArticlepeer-review


Background/Objectives:Evidence on the role of diet during adulthood and beyond on fracture occurrence is limited. We investigated diet and hip fracture incidence in a population of elderly Europeans, participants in the European Prospective Investigation into Cancer and nutrition study.Subjects/Methods:29 122 volunteers (10 538 men, 18 584 women) aged 60 years and above (mean age: 64.3) from five countries were followed up for a median of 8 years and 275 incident hip fractures (222 women and 53 men) were recorded. Diet was assessed at baseline through validated dietary questionnaires. Data were analyzed through Cox proportional-hazards regression with adjustment for potential confounders.Results:No food group or nutrient was significantly associated with hip fracture occurrence. There were suggestive inverse associations, however, with vegetable consumption (hazard ratio (HR) per increasing sex-specific quintile: 0.93, 95% confidence interval (CI): 0.85-1.01), fish consumption (HR per increasing sex-specific quintile: 0.93, 95% CI: 0.85-1.02) and polyunsaturated lipid intake (HR per increasing sex-specific quintile: 0.92, 95% CI: 0.82-1.02), whereas saturated lipid intake was positively associated with hip fracture risk (HR per increasing sex-specific quintile: 1.13, 95% CI: 0.99-1.29). Consumption of dairy products did not appear to influence the risk (HR per increasing sex-specific quintile: 1.02, 95% CI: 0.93-1.12).Conclusions: In a prospective study of the elderly, diet, including consumption of dairy products, alcohol and vitamin D, did not appear to play a major role in hip fracture incidence. There is however, weak and statistically non-significant evidence that vegetable and fish consumption and intake of polyunsaturated lipids may have a beneficial, whereas saturated lipid intake a detrimental effect.

Original languageEnglish
Pages (from-to)132-139
Number of pages8
JournalEuropean Journal of Clinical Nutrition
Issue number1
Publication statusPublished - Jan 2011


  • diet
  • elderly
  • hip fractures
  • nutrients
  • risk factors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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