Diet and hip fractures among elderly Europeans in the EPIC cohort

V. Benetou, P. Orfanos, D. Zylis, S. Sieri, P. Contiero, R. Tumino, M. C. Giurdanella, P. H M Peeters, J. Linseisen, A. Nieters, H. Boeing, C. Weikert, U. Pettersson, I. Johansson, H. B. Bueno-De-Mesquita, M. Dorronsoro, P. Boffetta, A. Trichopoulou

Research output: Contribution to journalArticle

Abstract

Background/Objectives:Evidence on the role of diet during adulthood and beyond on fracture occurrence is limited. We investigated diet and hip fracture incidence in a population of elderly Europeans, participants in the European Prospective Investigation into Cancer and nutrition study.Subjects/Methods:29 122 volunteers (10 538 men, 18 584 women) aged 60 years and above (mean age: 64.3) from five countries were followed up for a median of 8 years and 275 incident hip fractures (222 women and 53 men) were recorded. Diet was assessed at baseline through validated dietary questionnaires. Data were analyzed through Cox proportional-hazards regression with adjustment for potential confounders.Results:No food group or nutrient was significantly associated with hip fracture occurrence. There were suggestive inverse associations, however, with vegetable consumption (hazard ratio (HR) per increasing sex-specific quintile: 0.93, 95% confidence interval (CI): 0.85-1.01), fish consumption (HR per increasing sex-specific quintile: 0.93, 95% CI: 0.85-1.02) and polyunsaturated lipid intake (HR per increasing sex-specific quintile: 0.92, 95% CI: 0.82-1.02), whereas saturated lipid intake was positively associated with hip fracture risk (HR per increasing sex-specific quintile: 1.13, 95% CI: 0.99-1.29). Consumption of dairy products did not appear to influence the risk (HR per increasing sex-specific quintile: 1.02, 95% CI: 0.93-1.12).Conclusions: In a prospective study of the elderly, diet, including consumption of dairy products, alcohol and vitamin D, did not appear to play a major role in hip fracture incidence. There is however, weak and statistically non-significant evidence that vegetable and fish consumption and intake of polyunsaturated lipids may have a beneficial, whereas saturated lipid intake a detrimental effect.

Original languageEnglish
Pages (from-to)132-139
Number of pages8
JournalEuropean Journal of Clinical Nutrition
Volume65
Issue number1
DOIs
Publication statusPublished - Jan 2011

Fingerprint

Hip Fractures
Confidence Intervals
Diet
Lipids
Dairy Products
Vegetables
Fishes
Odds Ratio
Food
Incidence
Vitamin D
Volunteers
Alcohols
Prospective Studies
Population
Neoplasms

Keywords

  • diet
  • elderly
  • hip fractures
  • nutrients
  • risk factors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Diet and hip fractures among elderly Europeans in the EPIC cohort. / Benetou, V.; Orfanos, P.; Zylis, D.; Sieri, S.; Contiero, P.; Tumino, R.; Giurdanella, M. C.; Peeters, P. H M; Linseisen, J.; Nieters, A.; Boeing, H.; Weikert, C.; Pettersson, U.; Johansson, I.; Bueno-De-Mesquita, H. B.; Dorronsoro, M.; Boffetta, P.; Trichopoulou, A.

In: European Journal of Clinical Nutrition, Vol. 65, No. 1, 01.2011, p. 132-139.

Research output: Contribution to journalArticle

Benetou, V, Orfanos, P, Zylis, D, Sieri, S, Contiero, P, Tumino, R, Giurdanella, MC, Peeters, PHM, Linseisen, J, Nieters, A, Boeing, H, Weikert, C, Pettersson, U, Johansson, I, Bueno-De-Mesquita, HB, Dorronsoro, M, Boffetta, P & Trichopoulou, A 2011, 'Diet and hip fractures among elderly Europeans in the EPIC cohort', European Journal of Clinical Nutrition, vol. 65, no. 1, pp. 132-139. https://doi.org/10.1038/ejcn.2010.226
Benetou, V. ; Orfanos, P. ; Zylis, D. ; Sieri, S. ; Contiero, P. ; Tumino, R. ; Giurdanella, M. C. ; Peeters, P. H M ; Linseisen, J. ; Nieters, A. ; Boeing, H. ; Weikert, C. ; Pettersson, U. ; Johansson, I. ; Bueno-De-Mesquita, H. B. ; Dorronsoro, M. ; Boffetta, P. ; Trichopoulou, A. / Diet and hip fractures among elderly Europeans in the EPIC cohort. In: European Journal of Clinical Nutrition. 2011 ; Vol. 65, No. 1. pp. 132-139.
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abstract = "Background/Objectives:Evidence on the role of diet during adulthood and beyond on fracture occurrence is limited. We investigated diet and hip fracture incidence in a population of elderly Europeans, participants in the European Prospective Investigation into Cancer and nutrition study.Subjects/Methods:29 122 volunteers (10 538 men, 18 584 women) aged 60 years and above (mean age: 64.3) from five countries were followed up for a median of 8 years and 275 incident hip fractures (222 women and 53 men) were recorded. Diet was assessed at baseline through validated dietary questionnaires. Data were analyzed through Cox proportional-hazards regression with adjustment for potential confounders.Results:No food group or nutrient was significantly associated with hip fracture occurrence. There were suggestive inverse associations, however, with vegetable consumption (hazard ratio (HR) per increasing sex-specific quintile: 0.93, 95{\%} confidence interval (CI): 0.85-1.01), fish consumption (HR per increasing sex-specific quintile: 0.93, 95{\%} CI: 0.85-1.02) and polyunsaturated lipid intake (HR per increasing sex-specific quintile: 0.92, 95{\%} CI: 0.82-1.02), whereas saturated lipid intake was positively associated with hip fracture risk (HR per increasing sex-specific quintile: 1.13, 95{\%} CI: 0.99-1.29). Consumption of dairy products did not appear to influence the risk (HR per increasing sex-specific quintile: 1.02, 95{\%} CI: 0.93-1.12).Conclusions: In a prospective study of the elderly, diet, including consumption of dairy products, alcohol and vitamin D, did not appear to play a major role in hip fracture incidence. There is however, weak and statistically non-significant evidence that vegetable and fish consumption and intake of polyunsaturated lipids may have a beneficial, whereas saturated lipid intake a detrimental effect.",
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AU - Benetou, V.

AU - Orfanos, P.

AU - Zylis, D.

AU - Sieri, S.

AU - Contiero, P.

AU - Tumino, R.

AU - Giurdanella, M. C.

AU - Peeters, P. H M

AU - Linseisen, J.

AU - Nieters, A.

AU - Boeing, H.

AU - Weikert, C.

AU - Pettersson, U.

AU - Johansson, I.

AU - Bueno-De-Mesquita, H. B.

AU - Dorronsoro, M.

AU - Boffetta, P.

AU - Trichopoulou, A.

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N2 - Background/Objectives:Evidence on the role of diet during adulthood and beyond on fracture occurrence is limited. We investigated diet and hip fracture incidence in a population of elderly Europeans, participants in the European Prospective Investigation into Cancer and nutrition study.Subjects/Methods:29 122 volunteers (10 538 men, 18 584 women) aged 60 years and above (mean age: 64.3) from five countries were followed up for a median of 8 years and 275 incident hip fractures (222 women and 53 men) were recorded. Diet was assessed at baseline through validated dietary questionnaires. Data were analyzed through Cox proportional-hazards regression with adjustment for potential confounders.Results:No food group or nutrient was significantly associated with hip fracture occurrence. There were suggestive inverse associations, however, with vegetable consumption (hazard ratio (HR) per increasing sex-specific quintile: 0.93, 95% confidence interval (CI): 0.85-1.01), fish consumption (HR per increasing sex-specific quintile: 0.93, 95% CI: 0.85-1.02) and polyunsaturated lipid intake (HR per increasing sex-specific quintile: 0.92, 95% CI: 0.82-1.02), whereas saturated lipid intake was positively associated with hip fracture risk (HR per increasing sex-specific quintile: 1.13, 95% CI: 0.99-1.29). Consumption of dairy products did not appear to influence the risk (HR per increasing sex-specific quintile: 1.02, 95% CI: 0.93-1.12).Conclusions: In a prospective study of the elderly, diet, including consumption of dairy products, alcohol and vitamin D, did not appear to play a major role in hip fracture incidence. There is however, weak and statistically non-significant evidence that vegetable and fish consumption and intake of polyunsaturated lipids may have a beneficial, whereas saturated lipid intake a detrimental effect.

AB - Background/Objectives:Evidence on the role of diet during adulthood and beyond on fracture occurrence is limited. We investigated diet and hip fracture incidence in a population of elderly Europeans, participants in the European Prospective Investigation into Cancer and nutrition study.Subjects/Methods:29 122 volunteers (10 538 men, 18 584 women) aged 60 years and above (mean age: 64.3) from five countries were followed up for a median of 8 years and 275 incident hip fractures (222 women and 53 men) were recorded. Diet was assessed at baseline through validated dietary questionnaires. Data were analyzed through Cox proportional-hazards regression with adjustment for potential confounders.Results:No food group or nutrient was significantly associated with hip fracture occurrence. There were suggestive inverse associations, however, with vegetable consumption (hazard ratio (HR) per increasing sex-specific quintile: 0.93, 95% confidence interval (CI): 0.85-1.01), fish consumption (HR per increasing sex-specific quintile: 0.93, 95% CI: 0.85-1.02) and polyunsaturated lipid intake (HR per increasing sex-specific quintile: 0.92, 95% CI: 0.82-1.02), whereas saturated lipid intake was positively associated with hip fracture risk (HR per increasing sex-specific quintile: 1.13, 95% CI: 0.99-1.29). Consumption of dairy products did not appear to influence the risk (HR per increasing sex-specific quintile: 1.02, 95% CI: 0.93-1.12).Conclusions: In a prospective study of the elderly, diet, including consumption of dairy products, alcohol and vitamin D, did not appear to play a major role in hip fracture incidence. There is however, weak and statistically non-significant evidence that vegetable and fish consumption and intake of polyunsaturated lipids may have a beneficial, whereas saturated lipid intake a detrimental effect.

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