Diet, physical activity, and gallstones-a population-based, case- control study in Southern Italy

Giovanni Misciagna, Sandro Centonze, Claudio Leoci, Vito Guerra, Anna Maria Cisternino, Rosa Ceo, Maurizio Trevisan

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Background: Gallstones are a highly prevalent condition; however, the nutritional and lifestyle risk factors of this disease are not well understood. Objective: We evaluated the association between diet, physical activity, and incident cases of gallstones diagnosed by ultrasound in a population-based, case-control study. Design: One hundred patients with newly diagnosed gallstones and 290 randomly selected control subjects without gallstones were enrolled in the study. The presence of gallstones was determined by ultrasonography. Both patients and control subjects completed a questionnaire about their usual diet and physical activity for the 12 mo before the ultrasonography. The association between diet and physical activity and risk of gallstone formation was analyzed by using multiple logistic regression. Results: Body mass index and intake of refined sugars were directly associated with risk of gallstone formation, whereas physical activity, dietary monounsaturated fats, dietary cholesterol, and dietary fibers from cellulose were inversely associated with risk of gallstone formation. Saturated fats were a risk factor for gallstone formation and the association appeared to be stronger for men than for women. Conclusion: These findings suggest that a sedentary lifestyle and a diet rich in animal fats and refined sugars and poor in vegetable fats and fibers are significant risk factors for gallstone formation.

Original languageEnglish
Pages (from-to)120-126
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume69
Issue number1
Publication statusPublished - Jan 1999

Fingerprint

cholelithiasis
Gallstones
case-control studies
physical activity
Italy
Case-Control Studies
Exercise
Diet
diet
Population
refined sugar
risk factors
Fats
ultrasonography
Ultrasonography
dietary fiber
Sedentary Lifestyle
Dietary Cholesterol
plant fats
animal fats and oils

Keywords

  • Adults
  • Case-control study
  • Cholesterol
  • Diet
  • Fiber
  • Gallstones
  • Humans
  • Mediterranean diet
  • Monounsaturated fats
  • Physical activity
  • Saturated fats
  • Southern Italy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Misciagna, G., Centonze, S., Leoci, C., Guerra, V., Cisternino, A. M., Ceo, R., & Trevisan, M. (1999). Diet, physical activity, and gallstones-a population-based, case- control study in Southern Italy. American Journal of Clinical Nutrition, 69(1), 120-126.

Diet, physical activity, and gallstones-a population-based, case- control study in Southern Italy. / Misciagna, Giovanni; Centonze, Sandro; Leoci, Claudio; Guerra, Vito; Cisternino, Anna Maria; Ceo, Rosa; Trevisan, Maurizio.

In: American Journal of Clinical Nutrition, Vol. 69, No. 1, 01.1999, p. 120-126.

Research output: Contribution to journalArticle

Misciagna, G, Centonze, S, Leoci, C, Guerra, V, Cisternino, AM, Ceo, R & Trevisan, M 1999, 'Diet, physical activity, and gallstones-a population-based, case- control study in Southern Italy', American Journal of Clinical Nutrition, vol. 69, no. 1, pp. 120-126.
Misciagna, Giovanni ; Centonze, Sandro ; Leoci, Claudio ; Guerra, Vito ; Cisternino, Anna Maria ; Ceo, Rosa ; Trevisan, Maurizio. / Diet, physical activity, and gallstones-a population-based, case- control study in Southern Italy. In: American Journal of Clinical Nutrition. 1999 ; Vol. 69, No. 1. pp. 120-126.
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