Diet transiently improves migraine in two twin sisters: Possible role of ketogenesis?

Cherubino Di Lorenzo, Antonio Currà, Giulio Sirianni, Gianluca Coppola, Martina Bracaglia, Alessandra Cardillo, Lorenzo De Nardis, Francesco Pierelli

Research output: Contribution to journalArticlepeer-review

Abstract

The ketogenic diet is a high-fat, low-carbohydrate diet long used to treat refractory epilepsy; ketogenesis (ketone body formation) is a physiological phenomenon also observed in patients following lowcarbohydrate, low-calorie diets prescribed for rapid weight loss. We report the case of a pair of twin sisters, whose high-frequency migraine improved during a ketogenic diet they followed in order to lose weight. The observed time-lock between ketogenesis and migraine improvement provides some insight into how ketones act to improve migraine.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalFunctional Neurology
Volume28
Issue number4
Publication statusPublished - 2014

Keywords

  • Ketogenic diet
  • Migraine
  • Prophylaxis
  • Weight loss

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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