Dietary and red blood cell fatty acid changes after a four-year dietary intervention in the Rome Project of Coronary Heart Disease Prevention

F. Angelico, P. Amodeo, P. Guccione

Research output: Contribution to journalArticlepeer-review

Abstract

A program of dietary intervention has been carried out within the framework of the Rome Project of Coronary Heart Disease Prevention (PPCC), Italian section of the WHO Multifactor Preventive Trial of Coronary Heart Disease. Dietary prescriptions aimed at lowering serum cholesterol were given individually to all high-risk men, which non-high-risk men were exposed to collective health education. By the end of the fourth year, dietary changes which had occurred in subsamples of subjects belonging to both treatment and control groups were evaluated through dietary investigations and through the determination of red blood cell fatty acid patterns. The treatment group showed remarkably higher erythrocyte Linoleic/Oleic, Linoleic/Palmitic and Polyunsaturated/Saturated ratios. The lower percent content of erythrocyte saturated and monounsaturated fatty acids observed in the treatment group is in accordance with our main purpose, i.e. reduced intake of animal fat. Individually treated high-risk men showed more pronounced changes in erythrocyte fatty acid composition, as well as in dietary habits. Although poor compliance to dietary prescriptions was observed in several subjects, and only 50% could be defined as good adherers, a significant decrease was obtained in mean cholesterol levels.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalClinica e Terapia Cardiovascolare
Volume1
Issue number1
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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