TY - JOUR
T1 - Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study
AU - González, Carlos A.
AU - Travier, Noemie
AU - Luján-Barroso, Leila
AU - Castellsagué, Xavier
AU - Bosch, F. Xavier
AU - Roura, Esther
AU - Bueno-De-Mesquita, H. Bas
AU - Palli, Domenico
AU - Boeing, Heiner
AU - Pala, Valeria
AU - Sacerdote, Carlotta
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Manjer, Jonas
AU - Dillner, Joakim
AU - Hallmans, Göran
AU - Kjellberg, Lennart
AU - Sanchez, María José
AU - Altzibar, Jone M.
AU - Barricarte, Aurelio
AU - Navarro, Carmen
AU - Rodriguez, Laudina
AU - Allen, Naomi
AU - Key, Timothy J.
AU - Kaaks, Rudolf
AU - Rohrmann, Sabine
AU - Overvad, Kim
AU - Olsen, Anja
AU - Tjønneland, Anne
AU - Munk, Christian
AU - Kjaer, Susanne Krüger
AU - Peeters, Petra H M
AU - Van Duijnhoven, Fränzel J B
AU - Clavel-Chapelon, Françoise
AU - Boutron-Ruault, Marie Christine
AU - Trichopoulou, Antonia
AU - Benetou, Vasiliki
AU - Naska, Androniki
AU - Lund, Eiliv
AU - Engeset, Dagrun
AU - Skeie, Guri
AU - Franceschi, Silvia
AU - Slimani, Nadia
AU - Rinaldi, Sabina
AU - Riboli, Elio
PY - 2011/7/15
Y1 - 2011/7/15
N2 - Some dietary factors could be involved as cofactors in cervical carcinogenesis, but evidence is inconclusive. There are no data about the effect of fruits and vegetables intake (F&V) on cervical cancer from cohort studies. We examined the association between the intake of F&V and selected nutrients and the incidence of carcinoma in situ (CIS) and invasive squamous cervical cancer (ISC) in a prospective study of 299,649 women, participating in the European Prospective Investigation into Cancer and Nutrition study. Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CI). A calibration study was used to control measurement errors in the dietary questionnaire. After a mean of 9 years of follow-up, 253 ISC and 817 CIS cases were diagnosed. In the calibrated model, we observed a statistically significant inverse association of ISC with a daily increase in intake of 100 g of total fruits (HR 0.83; 95% CI 0.72-0.98) and a statistically nonsignificant inverse association with a daily increase in intake of 100 g of total vegetables (HR 0.85: 95% CI 0.65-1.10). Statistically nonsignificant inverse associations were also observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E and retinol for ISC. No association was found regarding beta-carotene, vitamin D and folic acid for ISC. None of the dietary factors examined was associated with CIS. Our study suggests a possible protective role of fruit intake and other dietary factors on ISC that need to be confirmed on a larger number of ISC cases.
AB - Some dietary factors could be involved as cofactors in cervical carcinogenesis, but evidence is inconclusive. There are no data about the effect of fruits and vegetables intake (F&V) on cervical cancer from cohort studies. We examined the association between the intake of F&V and selected nutrients and the incidence of carcinoma in situ (CIS) and invasive squamous cervical cancer (ISC) in a prospective study of 299,649 women, participating in the European Prospective Investigation into Cancer and Nutrition study. Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CI). A calibration study was used to control measurement errors in the dietary questionnaire. After a mean of 9 years of follow-up, 253 ISC and 817 CIS cases were diagnosed. In the calibrated model, we observed a statistically significant inverse association of ISC with a daily increase in intake of 100 g of total fruits (HR 0.83; 95% CI 0.72-0.98) and a statistically nonsignificant inverse association with a daily increase in intake of 100 g of total vegetables (HR 0.85: 95% CI 0.65-1.10). Statistically nonsignificant inverse associations were also observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E and retinol for ISC. No association was found regarding beta-carotene, vitamin D and folic acid for ISC. None of the dietary factors examined was associated with CIS. Our study suggests a possible protective role of fruit intake and other dietary factors on ISC that need to be confirmed on a larger number of ISC cases.
KW - Cervical cancer
KW - Cohort study
KW - Foods and nutrients intake
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U2 - 10.1002/ijc.25679
DO - 10.1002/ijc.25679
M3 - Article
C2 - 20853322
AN - SCOPUS:79961117212
VL - 129
SP - 449
EP - 459
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 2
ER -