TY - JOUR
T1 - Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition
AU - Sieri, Sabina
AU - Krogh, Vittorio
AU - Ferrari, Pietro
AU - Berrino, Franco
AU - Pala, Valeria
AU - Thiébaut, Anne C M
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Overvad, Kim
AU - Jakobsen, Marianne Uhre
AU - Clavel-Chapelon, Francoise
AU - Chajes, Veronique
AU - Boutron-Ruault, Marie Christine
AU - Kaaks, Rudolf
AU - Linseisen, Jakob
AU - Boeing, Heiner
AU - Nöthlings, Ute
AU - Trichopoulou, Antonia
AU - Naska, Androniki
AU - Lagiou, Pagona
AU - Panico, Salvatore
AU - Palli, Domenico
AU - Vineis, Paolo
AU - Tumino, Rosario
AU - Lund, Eiliv
AU - Kumle, Merethe
AU - Skeie, Guri
AU - González, Carlos A.
AU - Ardanaz, Eva
AU - Amiano, Pilar
AU - Tormo, María José
AU - Martínez-García, Carmen
AU - Quirós, Jose R.
AU - Berglund, Göran
AU - Gullberg, Bo
AU - Hallmans, Göran
AU - Lenner, Per
AU - Bueno-de-Mesquita, H. Bas
AU - Van Duijnhoven, Fränzel J B
AU - Peeters, Petra H M
AU - Van Gils, Carla H.
AU - Key, Timothy J.
AU - Crowe, Francesca L.
AU - Bingham, Sheila
AU - Khaw, Kay Tee
AU - Rinaldi, Sabina
AU - Slimani, Nadia
AU - Jenab, Mazda
AU - Norat, Teresa
AU - Riboli, Elio
PY - 2008/11/1
Y1 - 2008/11/1
N2 - Background: Epidemiologic studies have produced conflicting results with respect to an association of dietary fat with breast cancer. Objective: We aimed to investigate the association between fat consumption and breast cancer. Design: We prospectively investigated fat consumption in a large (n = 319 826), geographically and culturally heterogeneous cohort of European women enrolled in the European Prospective Investigation into Cancer and Nutrition who completed a dietary questionnaire. After a mean of 8.8 y of follow-up, 7119 women developed breast cancer. Cox proportional hazard models, stratified by age and center and adjusted for energy intake and confounders, were used to estimate hazard ratios (HRs) for breast cancer. Results: An association between high saturated fat intake and greater breast cancer risk was found [HR = 1.13 (95% CI: 1.00, 1.27; P for trend = 0.038) for the highest quintile of saturated fat intake compared with the lowest quintile: 1.02 (1.00, 1.04) for a 20% increase in saturated fat consumption (continuous variable)]. No significant association of breast cancer with total, monounsaturated, or polyunsaturated fat was found, although trends were for a direct association of risk with monounsaturated fat and an inverse association with polyunsaturated fat. In menopausal women, the positive association with saturated fat was confined to nonusers of hormone therapy at baseline [1.21 (0.99, 1.48) for the highest quintile compared with the lowest quintile; P for trend = 0.044; and 1.03 (1.00, 1.07) for a 20% increase in saturated fat as a continuous variable]. Conclusions: Evidence indicates a weak positive association between saturated fat intake and breast cancer risk. This association was more pronounced for postmenopausal women who never used hormone therapy.
AB - Background: Epidemiologic studies have produced conflicting results with respect to an association of dietary fat with breast cancer. Objective: We aimed to investigate the association between fat consumption and breast cancer. Design: We prospectively investigated fat consumption in a large (n = 319 826), geographically and culturally heterogeneous cohort of European women enrolled in the European Prospective Investigation into Cancer and Nutrition who completed a dietary questionnaire. After a mean of 8.8 y of follow-up, 7119 women developed breast cancer. Cox proportional hazard models, stratified by age and center and adjusted for energy intake and confounders, were used to estimate hazard ratios (HRs) for breast cancer. Results: An association between high saturated fat intake and greater breast cancer risk was found [HR = 1.13 (95% CI: 1.00, 1.27; P for trend = 0.038) for the highest quintile of saturated fat intake compared with the lowest quintile: 1.02 (1.00, 1.04) for a 20% increase in saturated fat consumption (continuous variable)]. No significant association of breast cancer with total, monounsaturated, or polyunsaturated fat was found, although trends were for a direct association of risk with monounsaturated fat and an inverse association with polyunsaturated fat. In menopausal women, the positive association with saturated fat was confined to nonusers of hormone therapy at baseline [1.21 (0.99, 1.48) for the highest quintile compared with the lowest quintile; P for trend = 0.044; and 1.03 (1.00, 1.07) for a 20% increase in saturated fat as a continuous variable]. Conclusions: Evidence indicates a weak positive association between saturated fat intake and breast cancer risk. This association was more pronounced for postmenopausal women who never used hormone therapy.
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U2 - 10.3945/ajcn.2008.26090
DO - 10.3945/ajcn.2008.26090
M3 - Article
C2 - 18996867
AN - SCOPUS:55849096928
VL - 88
SP - 1304
EP - 1312
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 5
ER -