Dietary fat intake and development of specific breast cancer subtypes.

Sabina Sieri, Paolo Chiodini, Claudia Agnoli, Valeria Pala, Franco Berrino, Antonia Trichopoulou, Vassiliki Benetou, Effie Vasilopoulou, María José Sánchez, Maria Dolores Chirlaque, Pilar Amiano, J. Ramón Quirós, Eva Ardanaz, Genevieve Buckland, Giovanna Masala, Salvatore Panico, Sara Grioni, Carlotta Sacerdote, Rosario Tumino, Marie Christine Boutron-RuaultFrançoise Clavel-Chapelon, Guy Fagherazzi, Petra H M Peeters, Carla H. van Gils, H. Bas Bueno-de-Mesquita, Henk J. van Kranen, Timothy J. Key, Ruth C. Travis, Kay Tee Khaw, Nicholas J. Wareham, Rudolf Kaaks, Annekatrin Lukanova, Heiner Boeing, Madlen Schütze, Emily Sonestedt, Elisabeth Wirfält, Malin Sund, Anne Andersson, Veronique Chajes, Sabina Rinaldi, Isabelle Romieu, Elisabete Weiderpass, Guri Skeie, Engeset Dagrun, Anne Tjønneland, Jytte Halkjær, Kim Overvard, Melissa A. Merritt, David Cox, Elio Riboli, Vittorio Krogh

Research output: Contribution to journalArticle

Abstract

We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER(+)PR(+) disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER(-)PR(-) disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.

Original languageEnglish
JournalJournal of the National Cancer Institute
Volume106
Issue number5
Publication statusPublished - 2014

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Dietary Fats
Fats
Breast Neoplasms
Progesterone Receptors
Estrogen Receptors
Confidence Intervals

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Dietary fat intake and development of specific breast cancer subtypes. / Sieri, Sabina; Chiodini, Paolo; Agnoli, Claudia; Pala, Valeria; Berrino, Franco; Trichopoulou, Antonia; Benetou, Vassiliki; Vasilopoulou, Effie; Sánchez, María José; Chirlaque, Maria Dolores; Amiano, Pilar; Quirós, J. Ramón; Ardanaz, Eva; Buckland, Genevieve; Masala, Giovanna; Panico, Salvatore; Grioni, Sara; Sacerdote, Carlotta; Tumino, Rosario; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Françoise; Fagherazzi, Guy; Peeters, Petra H M; van Gils, Carla H.; Bueno-de-Mesquita, H. Bas; van Kranen, Henk J.; Key, Timothy J.; Travis, Ruth C.; Khaw, Kay Tee; Wareham, Nicholas J.; Kaaks, Rudolf; Lukanova, Annekatrin; Boeing, Heiner; Schütze, Madlen; Sonestedt, Emily; Wirfält, Elisabeth; Sund, Malin; Andersson, Anne; Chajes, Veronique; Rinaldi, Sabina; Romieu, Isabelle; Weiderpass, Elisabete; Skeie, Guri; Dagrun, Engeset; Tjønneland, Anne; Halkjær, Jytte; Overvard, Kim; Merritt, Melissa A.; Cox, David; Riboli, Elio; Krogh, Vittorio.

In: Journal of the National Cancer Institute, Vol. 106, No. 5, 2014.

Research output: Contribution to journalArticle

Sieri, S, Chiodini, P, Agnoli, C, Pala, V, Berrino, F, Trichopoulou, A, Benetou, V, Vasilopoulou, E, Sánchez, MJ, Chirlaque, MD, Amiano, P, Quirós, JR, Ardanaz, E, Buckland, G, Masala, G, Panico, S, Grioni, S, Sacerdote, C, Tumino, R, Boutron-Ruault, MC, Clavel-Chapelon, F, Fagherazzi, G, Peeters, PHM, van Gils, CH, Bueno-de-Mesquita, HB, van Kranen, HJ, Key, TJ, Travis, RC, Khaw, KT, Wareham, NJ, Kaaks, R, Lukanova, A, Boeing, H, Schütze, M, Sonestedt, E, Wirfält, E, Sund, M, Andersson, A, Chajes, V, Rinaldi, S, Romieu, I, Weiderpass, E, Skeie, G, Dagrun, E, Tjønneland, A, Halkjær, J, Overvard, K, Merritt, MA, Cox, D, Riboli, E & Krogh, V 2014, 'Dietary fat intake and development of specific breast cancer subtypes.', Journal of the National Cancer Institute, vol. 106, no. 5.
Sieri, Sabina ; Chiodini, Paolo ; Agnoli, Claudia ; Pala, Valeria ; Berrino, Franco ; Trichopoulou, Antonia ; Benetou, Vassiliki ; Vasilopoulou, Effie ; Sánchez, María José ; Chirlaque, Maria Dolores ; Amiano, Pilar ; Quirós, J. Ramón ; Ardanaz, Eva ; Buckland, Genevieve ; Masala, Giovanna ; Panico, Salvatore ; Grioni, Sara ; Sacerdote, Carlotta ; Tumino, Rosario ; Boutron-Ruault, Marie Christine ; Clavel-Chapelon, Françoise ; Fagherazzi, Guy ; Peeters, Petra H M ; van Gils, Carla H. ; Bueno-de-Mesquita, H. Bas ; van Kranen, Henk J. ; Key, Timothy J. ; Travis, Ruth C. ; Khaw, Kay Tee ; Wareham, Nicholas J. ; Kaaks, Rudolf ; Lukanova, Annekatrin ; Boeing, Heiner ; Schütze, Madlen ; Sonestedt, Emily ; Wirfält, Elisabeth ; Sund, Malin ; Andersson, Anne ; Chajes, Veronique ; Rinaldi, Sabina ; Romieu, Isabelle ; Weiderpass, Elisabete ; Skeie, Guri ; Dagrun, Engeset ; Tjønneland, Anne ; Halkjær, Jytte ; Overvard, Kim ; Merritt, Melissa A. ; Cox, David ; Riboli, Elio ; Krogh, Vittorio. / Dietary fat intake and development of specific breast cancer subtypes. In: Journal of the National Cancer Institute. 2014 ; Vol. 106, No. 5.
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abstract = "We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER(+)PR(+) disease (HR = 1.20, 95{\%} confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95{\%} CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER(-)PR(-) disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.",
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AU - Sieri, Sabina

AU - Chiodini, Paolo

AU - Agnoli, Claudia

AU - Pala, Valeria

AU - Berrino, Franco

AU - Trichopoulou, Antonia

AU - Benetou, Vassiliki

AU - Vasilopoulou, Effie

AU - Sánchez, María José

AU - Chirlaque, Maria Dolores

AU - Amiano, Pilar

AU - Quirós, J. Ramón

AU - Ardanaz, Eva

AU - Buckland, Genevieve

AU - Masala, Giovanna

AU - Panico, Salvatore

AU - Grioni, Sara

AU - Sacerdote, Carlotta

AU - Tumino, Rosario

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Françoise

AU - Fagherazzi, Guy

AU - Peeters, Petra H M

AU - van Gils, Carla H.

AU - Bueno-de-Mesquita, H. Bas

AU - van Kranen, Henk J.

AU - Key, Timothy J.

AU - Travis, Ruth C.

AU - Khaw, Kay Tee

AU - Wareham, Nicholas J.

AU - Kaaks, Rudolf

AU - Lukanova, Annekatrin

AU - Boeing, Heiner

AU - Schütze, Madlen

AU - Sonestedt, Emily

AU - Wirfält, Elisabeth

AU - Sund, Malin

AU - Andersson, Anne

AU - Chajes, Veronique

AU - Rinaldi, Sabina

AU - Romieu, Isabelle

AU - Weiderpass, Elisabete

AU - Skeie, Guri

AU - Dagrun, Engeset

AU - Tjønneland, Anne

AU - Halkjær, Jytte

AU - Overvard, Kim

AU - Merritt, Melissa A.

AU - Cox, David

AU - Riboli, Elio

AU - Krogh, Vittorio

PY - 2014

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