Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition

Melissa A. Merritt, Elio Riboli, Elisabete Weiderpass, Konstantinos K. Tsilidis, Kim Overvad, Anne Tjønneland, Louise Hansen, Laure Dossus, Guy Fagherazzi, Laura Baglietto, Renée T. Fortner, Jennifer Ose, Annika Steffen, Heiner Boeing, Antonia Trichopoulou, Dimitrios Trichopoulos, Pagona Lagiou, Giovanna Masala, Sabina Sieri, Amalia MattielloRosario Tumino, Carlotta Sacerdote, H. B(as) Bueno-de-Mesquita, N. Charlotte Onland-Moret, Petra H. Peeters, Anette Hjartåker, Inger Torhild Gram, J. Ramón Quirós, Mireia Obón-Santacana, Esther Molina-Montes, José María Huerta Castaño, Eva Ardanaz, Saioa Chamosa, Emily Sonestedt, Annika Idahl, Eva Lundin, Kay Tee Khaw, Nicholas Wareham, Ruth C. Travis, Sabina Rinaldi, Isabelle Romieu, Veronique Chajes, Marc J. Gunter

Research output: Contribution to journalArticle

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Abstract

There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n=96) EOC. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In multivariate models, we observed no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive EOC. There was, however, an increased risk of invasive EOC in the highest category of intake (Quartile 4 vs. Quartile 1) of polyunsaturated fat (HR=1.22, 95% CI=1.02-1.48, Ptrend=0.02). We did not observe heterogeneity in the risk associations in comparisons of serous and endometrioid histologic subtypes. This study does not support an etiological role for total fat intake in relation to EOC risk; however, based on observations of a positive association between intake of polyunsaturated fat and invasive EOC risk in the current and previous studies, this fat subtype warrants further investigation to determine its potential role in EOC development.

Original languageEnglish
Pages (from-to)528-537
Number of pages10
JournalCancer Epidemiology
Volume38
Issue number5
DOIs
Publication statusPublished - Oct 1 2014

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Dietary Fats
Fats
Neoplasms
Ovarian epithelial cancer
Confidence Intervals
Fishes
Cholesterol

Keywords

  • Dietary fats
  • Ovarian cancer
  • Serous neoplasms
  • Unsaturated dietary fats

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology

Cite this

Merritt, M. A., Riboli, E., Weiderpass, E., Tsilidis, K. K., Overvad, K., Tjønneland, A., ... Gunter, M. J. (2014). Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology, 38(5), 528-537. https://doi.org/10.1016/j.canep.2014.07.011

Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition. / Merritt, Melissa A.; Riboli, Elio; Weiderpass, Elisabete; Tsilidis, Konstantinos K.; Overvad, Kim; Tjønneland, Anne; Hansen, Louise; Dossus, Laure; Fagherazzi, Guy; Baglietto, Laura; Fortner, Renée T.; Ose, Jennifer; Steffen, Annika; Boeing, Heiner; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Lagiou, Pagona; Masala, Giovanna; Sieri, Sabina; Mattiello, Amalia; Tumino, Rosario; Sacerdote, Carlotta; Bueno-de-Mesquita, H. B(as); Onland-Moret, N. Charlotte; Peeters, Petra H.; Hjartåker, Anette; Gram, Inger Torhild; Quirós, J. Ramón; Obón-Santacana, Mireia; Molina-Montes, Esther; Huerta Castaño, José María; Ardanaz, Eva; Chamosa, Saioa; Sonestedt, Emily; Idahl, Annika; Lundin, Eva; Khaw, Kay Tee; Wareham, Nicholas; Travis, Ruth C.; Rinaldi, Sabina; Romieu, Isabelle; Chajes, Veronique; Gunter, Marc J.

In: Cancer Epidemiology, Vol. 38, No. 5, 01.10.2014, p. 528-537.

Research output: Contribution to journalArticle

Merritt, MA, Riboli, E, Weiderpass, E, Tsilidis, KK, Overvad, K, Tjønneland, A, Hansen, L, Dossus, L, Fagherazzi, G, Baglietto, L, Fortner, RT, Ose, J, Steffen, A, Boeing, H, Trichopoulou, A, Trichopoulos, D, Lagiou, P, Masala, G, Sieri, S, Mattiello, A, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, HB, Onland-Moret, NC, Peeters, PH, Hjartåker, A, Gram, IT, Quirós, JR, Obón-Santacana, M, Molina-Montes, E, Huerta Castaño, JM, Ardanaz, E, Chamosa, S, Sonestedt, E, Idahl, A, Lundin, E, Khaw, KT, Wareham, N, Travis, RC, Rinaldi, S, Romieu, I, Chajes, V & Gunter, MJ 2014, 'Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition', Cancer Epidemiology, vol. 38, no. 5, pp. 528-537. https://doi.org/10.1016/j.canep.2014.07.011
Merritt, Melissa A. ; Riboli, Elio ; Weiderpass, Elisabete ; Tsilidis, Konstantinos K. ; Overvad, Kim ; Tjønneland, Anne ; Hansen, Louise ; Dossus, Laure ; Fagherazzi, Guy ; Baglietto, Laura ; Fortner, Renée T. ; Ose, Jennifer ; Steffen, Annika ; Boeing, Heiner ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Lagiou, Pagona ; Masala, Giovanna ; Sieri, Sabina ; Mattiello, Amalia ; Tumino, Rosario ; Sacerdote, Carlotta ; Bueno-de-Mesquita, H. B(as) ; Onland-Moret, N. Charlotte ; Peeters, Petra H. ; Hjartåker, Anette ; Gram, Inger Torhild ; Quirós, J. Ramón ; Obón-Santacana, Mireia ; Molina-Montes, Esther ; Huerta Castaño, José María ; Ardanaz, Eva ; Chamosa, Saioa ; Sonestedt, Emily ; Idahl, Annika ; Lundin, Eva ; Khaw, Kay Tee ; Wareham, Nicholas ; Travis, Ruth C. ; Rinaldi, Sabina ; Romieu, Isabelle ; Chajes, Veronique ; Gunter, Marc J. / Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition. In: Cancer Epidemiology. 2014 ; Vol. 38, No. 5. pp. 528-537.
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AU - Sieri, Sabina

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Bueno-de-Mesquita, H. B(as)

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AU - Peeters, Petra H.

AU - Hjartåker, Anette

AU - Gram, Inger Torhild

AU - Quirós, J. Ramón

AU - Obón-Santacana, Mireia

AU - Molina-Montes, Esther

AU - Huerta Castaño, José María

AU - Ardanaz, Eva

AU - Chamosa, Saioa

AU - Sonestedt, Emily

AU - Idahl, Annika

AU - Lundin, Eva

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