Abstract
Currently available epidemiological evidence suggested that an increase of saturated fatty acids (SFA) could have negative effects on cognitive functions, while increased polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) may be protective against cognitive decline. In a Southern Italian elderly population from the Italian Longitudinal Study on Aging (ILSA), a clear reduction of risk of age-related cognitive decline (ARCD) has been found with elevated intake of PUFA and MUFA. Furthermore, in the ILSA, while dietary fatty acids intakes were not associated with incident mild cognitive impairment (MCI), high PUFA intake appeared to have borderline non-significant trend for a protective effect against the development of MCI. These epidemiological findings on predementia syndromes, i.e. MCI or ARCD, together with a recent randomised controlled trial on a possible effect on cognitive and depressive symptoms of -3 PUFA supplementation in patients with very mild AD, suggested a possible role of fatty acids intake in maintaining adequate cognitive functioning and possibly in preventing or delaying the onset of dementia.
| Original language | English |
|---|---|
| Pages (from-to) | 382-386 |
| Number of pages | 5 |
| Journal | Journal of Nutrition, Health and Aging |
| Volume | 12 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2008 |
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Keywords
- Age-related cognitive decline
- Alzheimer's disease
- Dementia
- fatty acids
- Mild cognitive impairment
- MUFA
- Predementia syndromes
- PUFA
- Vascular dementia
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Ageing
- Endocrinology
- Food Science
Cite this
Dietary fatty acids, age-related cognitive decline, and mild cognitive impairment. / Solfrlzzi, V.; Capurso, C.; D'Introno, A.; Colacicco, A. M.; Frisardi, V.; Santamato, A.; Ranieri, M.; Fiore, P.; Vendemiale, G.; Seripa, D.; Pilotto, A.; Capurso, A.; Panza, F.
In: Journal of Nutrition, Health and Aging, Vol. 12, No. 6, 06.2008, p. 382-386.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dietary fatty acids, age-related cognitive decline, and mild cognitive impairment
AU - Solfrlzzi, V.
AU - Capurso, C.
AU - D'Introno, A.
AU - Colacicco, A. M.
AU - Frisardi, V.
AU - Santamato, A.
AU - Ranieri, M.
AU - Fiore, P.
AU - Vendemiale, G.
AU - Seripa, D.
AU - Pilotto, A.
AU - Capurso, A.
AU - Panza, F.
PY - 2008/6
Y1 - 2008/6
N2 - Currently available epidemiological evidence suggested that an increase of saturated fatty acids (SFA) could have negative effects on cognitive functions, while increased polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) may be protective against cognitive decline. In a Southern Italian elderly population from the Italian Longitudinal Study on Aging (ILSA), a clear reduction of risk of age-related cognitive decline (ARCD) has been found with elevated intake of PUFA and MUFA. Furthermore, in the ILSA, while dietary fatty acids intakes were not associated with incident mild cognitive impairment (MCI), high PUFA intake appeared to have borderline non-significant trend for a protective effect against the development of MCI. These epidemiological findings on predementia syndromes, i.e. MCI or ARCD, together with a recent randomised controlled trial on a possible effect on cognitive and depressive symptoms of -3 PUFA supplementation in patients with very mild AD, suggested a possible role of fatty acids intake in maintaining adequate cognitive functioning and possibly in preventing or delaying the onset of dementia.
AB - Currently available epidemiological evidence suggested that an increase of saturated fatty acids (SFA) could have negative effects on cognitive functions, while increased polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) may be protective against cognitive decline. In a Southern Italian elderly population from the Italian Longitudinal Study on Aging (ILSA), a clear reduction of risk of age-related cognitive decline (ARCD) has been found with elevated intake of PUFA and MUFA. Furthermore, in the ILSA, while dietary fatty acids intakes were not associated with incident mild cognitive impairment (MCI), high PUFA intake appeared to have borderline non-significant trend for a protective effect against the development of MCI. These epidemiological findings on predementia syndromes, i.e. MCI or ARCD, together with a recent randomised controlled trial on a possible effect on cognitive and depressive symptoms of -3 PUFA supplementation in patients with very mild AD, suggested a possible role of fatty acids intake in maintaining adequate cognitive functioning and possibly in preventing or delaying the onset of dementia.
KW - Age-related cognitive decline
KW - Alzheimer's disease
KW - Dementia
KW - fatty acids
KW - Mild cognitive impairment
KW - MUFA
KW - Predementia syndromes
KW - PUFA
KW - Vascular dementia
UR - http://www.scopus.com/inward/record.url?scp=46849083940&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46849083940&partnerID=8YFLogxK
U2 - 10.1007/BF02982670
DO - 10.1007/BF02982670
M3 - Article
VL - 12
SP - 382
EP - 386
JO - Journal of Nutrition, Health and Aging
JF - Journal of Nutrition, Health and Aging
SN - 1279-7707
IS - 6
ER -