Dietary Fatty Acids and Microbiota-Brain Communication in Neuropsychiatric Diseases

Maria Cristina Marrone, Roberto Coccurello

Research output: Contribution to journalReview articlepeer-review


The gut-brain axis is a multimodal communication system along which immune, metabolic, autonomic, endocrine and enteric nervous signals can shape host physiology and determine liability, development and progression of a vast number of human diseases. Here, we broadly discussed the current knowledge about the either beneficial or deleterious impact of dietary fatty acids on microbiota-brain communication (MBC), and the multiple mechanisms by which different types of lipids can modify gut microbial ecosystem and contribute to the pathophysiology of major neuropsychiatric diseases (NPDs), such as schizophrenia (SCZ), depression and autism spectrum disorders (ASD).

Original languageEnglish
Issue number1
Publication statusPublished - Dec 19 2019


  • depression
  • dietary fatty acids
  • microbiota-brain communication
  • polyunsaturated fatty acids
  • schizophrenia

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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