Dietary fiber intake and risk of colorectal cancer: A pooled analysis of prospective cohort studies

Yikyung Park, David J. Hunter, Donna Spiegelman, Leif Bergkvist, Franco Berrino, Piet A. Van Den Brandt, Julie E. Buring, Graham A. Colditz, Jo L. Freudenheim, Charles S. Fuchs, Edward Giovannucci, R. Alexandra Goldbohm, Saxon Graham, Lisa Harnack, Anne M. Hartman, David R. Jacobs, Ikuko Kato, Vittorio Krogh, Michael F. Leitzmann, Marjorie L. McCulloughAnthony B. Miller, Pirjo Pietinen, Thomas E. Rohan, Arthur Schatzkin, Walter C. Willett, Alicja Wolk, Anne Zeleniuch-Jacquotte, Shumin M. Zhang, Stephanie A. Smith-Warner

Research output: Contribution to journalArticlepeer-review


Context: Inconsistent findings from observational studies have continued the controversy over the effects of dietary fiber on colorectal cancer. Objective: To evaluate the association between dietary fiber intake and risk of colorectal cancer. Design, Setting, and Participants: From 13 prospective cohort studies included in the Pooling Project of Prospective Studies of Diet and Cancer, 725 628 men and women were followed up for 6 to 20 years across studies. Study- and sex-specific relative risks (RRs) were estimated with the Cox proportional hazards model and were subsequently pooled using a random-effects model. Main Outcome Measure: Incident colorectal cancer. Results: During 6 to 20 years of follow-up across studies, 8081 colorectal cancer cases were identified. For comparison of the highest vs lowest study- and sex-specific quintile of dietary fiber intake, a significant inverse association was found in the age-adjusted model (pooled RR=0.84; 95% confidence interval [CI], 0.77-0.92). However, the association was attenuated and no longer statistically significant after adjusting for other risk factors (pooled multivariate RR=0.94; 95% CI, 0.86-1.03). In categorical analyses compared with dietary fiber intake of 10 to

Original languageEnglish
Pages (from-to)2849-2857
Number of pages9
JournalJournal of the American Medical Association
Issue number22
Publication statusPublished - Dec 14 2005

ASJC Scopus subject areas

  • Medicine(all)


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