Dietary fiber intake and risk of hormonal receptor-defined breast cancer in the European prospective investigation into cancer and nutrition study

Pietro Ferrari, Sabina Rinaldi, Mazda Jenab, Annekatrin Lukanova, Anja Olsen, Anne Tjønneland, Kim Overvad, Françoise Clavel-Chapelon, Guy Fagherazzi, Marina Touillaud, Rudolf Kaaks, Anne Von Rüsten, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Vassiliki Benetou, Sara Grioni, Salvatore Panico, Giovanna Masala, Rosario Tumino & 25 others Silvia Polidoro, Marije F. Bakker, Carla H. Van Gils, Martine M. Ros, H. Bas Bueno-de-Mesquita, Sanda Krum-Hansen, Dagrun Engeset, Guri Skeie, Amiano Pilar, Maria José Sánchez, Genevieve Buckland, Eva Ardanaz, Dolores Chirlaque, Laudina Rodriguez, Ruth Travis, Tim Key, Kay Tee Khaw, Nicholas J. Wareham, Malin Sund, Per Lenner, Nadia Slimani, Teresa Norat, Dagfinn Aune, Elio Riboli, Isabelle Romieu

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Background: Limited scientific evidence has characterized the association between dietary fiber intake and risk of breast cancer (BC) by menopausal status and hormone receptor expression in tumors. Objective: We investigated the relation between total dietary fiber and its main food sources (vegetables fruit cereals and legumes) and BC risk by using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: A total of 11,576 invasive BC cases in 334,849 EPIC women mostly aged 35-70 y at baseline were identified over a median follow-up of 11.5 y. Dietary fiber was estimated from country-specific dietary questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk with energy adjustment by using the residual method. Subgroup analyses were performed by menopausal status and estrogen receptor (ER) and progesterone receptor (PR) expression in tumors. Results: BC risk was inversely associated with intakes of total dietary fiber [hazard ratio comparing fifth quintile to first quintile (HRQ5-Q1): 0.95; 95% CI: 0.89 1.01; P-trend = 0.03] and fiber from vegetables (0.90; 0.84 0.96; P-trend <0.01) but not with fiber from fruit cereals or legumes. Overall associations were homogeneous by menopausal status and ER and PR expression in tumors. For vegetable fiber stronger associations were observed for estrogen receptor-negative and progesterone receptor-negative (HRQ5-Q1:0.74; 95% CI: 0.59 0.93; P-trend = 0.01) than for estrogen receptor-positive and progesterone receptor-positive tumors (0.92: 0.81 1.03; P-trend = 0.05) with P-heterogeneity = 0.09. Conclusion: Diets rich in dietary fiber and particularly fiber from vegetables may be associated with a small reduction in risk of BC independently of menopausal status.

Original languageEnglish
Pages (from-to)344-353
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume97
Issue number2
DOIs
Publication statusPublished - Feb 1 2013

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Dietary Fiber
Progesterone Receptors
Breast Neoplasms
Estrogen Receptors
Vegetables
Neoplasms
Fabaceae
Fruit
Social Adjustment
Risk Reduction Behavior
Proportional Hazards Models
Hormones
Diet
Food

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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Dietary fiber intake and risk of hormonal receptor-defined breast cancer in the European prospective investigation into cancer and nutrition study. / Ferrari, Pietro; Rinaldi, Sabina; Jenab, Mazda; Lukanova, Annekatrin; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Clavel-Chapelon, Françoise; Fagherazzi, Guy; Touillaud, Marina; Kaaks, Rudolf; Von Rüsten, Anne; Boeing, Heiner; Trichopoulou, Antonia; Lagiou, Pagona; Benetou, Vassiliki; Grioni, Sara; Panico, Salvatore; Masala, Giovanna; Tumino, Rosario; Polidoro, Silvia; Bakker, Marije F.; Van Gils, Carla H.; Ros, Martine M.; Bueno-de-Mesquita, H. Bas; Krum-Hansen, Sanda; Engeset, Dagrun; Skeie, Guri; Pilar, Amiano; Sánchez, Maria José; Buckland, Genevieve; Ardanaz, Eva; Chirlaque, Dolores; Rodriguez, Laudina; Travis, Ruth; Key, Tim; Khaw, Kay Tee; Wareham, Nicholas J.; Sund, Malin; Lenner, Per; Slimani, Nadia; Norat, Teresa; Aune, Dagfinn; Riboli, Elio; Romieu, Isabelle.

In: American Journal of Clinical Nutrition, Vol. 97, No. 2, 01.02.2013, p. 344-353.

Research output: Contribution to journalArticle

Ferrari, P, Rinaldi, S, Jenab, M, Lukanova, A, Olsen, A, Tjønneland, A, Overvad, K, Clavel-Chapelon, F, Fagherazzi, G, Touillaud, M, Kaaks, R, Von Rüsten, A, Boeing, H, Trichopoulou, A, Lagiou, P, Benetou, V, Grioni, S, Panico, S, Masala, G, Tumino, R, Polidoro, S, Bakker, MF, Van Gils, CH, Ros, MM, Bueno-de-Mesquita, HB, Krum-Hansen, S, Engeset, D, Skeie, G, Pilar, A, Sánchez, MJ, Buckland, G, Ardanaz, E, Chirlaque, D, Rodriguez, L, Travis, R, Key, T, Khaw, KT, Wareham, NJ, Sund, M, Lenner, P, Slimani, N, Norat, T, Aune, D, Riboli, E & Romieu, I 2013, 'Dietary fiber intake and risk of hormonal receptor-defined breast cancer in the European prospective investigation into cancer and nutrition study', American Journal of Clinical Nutrition, vol. 97, no. 2, pp. 344-353. https://doi.org/10.3945/ajcn.112.034025
Ferrari, Pietro ; Rinaldi, Sabina ; Jenab, Mazda ; Lukanova, Annekatrin ; Olsen, Anja ; Tjønneland, Anne ; Overvad, Kim ; Clavel-Chapelon, Françoise ; Fagherazzi, Guy ; Touillaud, Marina ; Kaaks, Rudolf ; Von Rüsten, Anne ; Boeing, Heiner ; Trichopoulou, Antonia ; Lagiou, Pagona ; Benetou, Vassiliki ; Grioni, Sara ; Panico, Salvatore ; Masala, Giovanna ; Tumino, Rosario ; Polidoro, Silvia ; Bakker, Marije F. ; Van Gils, Carla H. ; Ros, Martine M. ; Bueno-de-Mesquita, H. Bas ; Krum-Hansen, Sanda ; Engeset, Dagrun ; Skeie, Guri ; Pilar, Amiano ; Sánchez, Maria José ; Buckland, Genevieve ; Ardanaz, Eva ; Chirlaque, Dolores ; Rodriguez, Laudina ; Travis, Ruth ; Key, Tim ; Khaw, Kay Tee ; Wareham, Nicholas J. ; Sund, Malin ; Lenner, Per ; Slimani, Nadia ; Norat, Teresa ; Aune, Dagfinn ; Riboli, Elio ; Romieu, Isabelle. / Dietary fiber intake and risk of hormonal receptor-defined breast cancer in the European prospective investigation into cancer and nutrition study. In: American Journal of Clinical Nutrition. 2013 ; Vol. 97, No. 2. pp. 344-353.
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abstract = "Background: Limited scientific evidence has characterized the association between dietary fiber intake and risk of breast cancer (BC) by menopausal status and hormone receptor expression in tumors. Objective: We investigated the relation between total dietary fiber and its main food sources (vegetables fruit cereals and legumes) and BC risk by using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: A total of 11,576 invasive BC cases in 334,849 EPIC women mostly aged 35-70 y at baseline were identified over a median follow-up of 11.5 y. Dietary fiber was estimated from country-specific dietary questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk with energy adjustment by using the residual method. Subgroup analyses were performed by menopausal status and estrogen receptor (ER) and progesterone receptor (PR) expression in tumors. Results: BC risk was inversely associated with intakes of total dietary fiber [hazard ratio comparing fifth quintile to first quintile (HRQ5-Q1): 0.95; 95{\%} CI: 0.89 1.01; P-trend = 0.03] and fiber from vegetables (0.90; 0.84 0.96; P-trend <0.01) but not with fiber from fruit cereals or legumes. Overall associations were homogeneous by menopausal status and ER and PR expression in tumors. For vegetable fiber stronger associations were observed for estrogen receptor-negative and progesterone receptor-negative (HRQ5-Q1:0.74; 95{\%} CI: 0.59 0.93; P-trend = 0.01) than for estrogen receptor-positive and progesterone receptor-positive tumors (0.92: 0.81 1.03; P-trend = 0.05) with P-heterogeneity = 0.09. Conclusion: Diets rich in dietary fiber and particularly fiber from vegetables may be associated with a small reduction in risk of BC independently of menopausal status.",
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T1 - Dietary fiber intake and risk of hormonal receptor-defined breast cancer in the European prospective investigation into cancer and nutrition study

AU - Ferrari, Pietro

AU - Rinaldi, Sabina

AU - Jenab, Mazda

AU - Lukanova, Annekatrin

AU - Olsen, Anja

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Clavel-Chapelon, Françoise

AU - Fagherazzi, Guy

AU - Touillaud, Marina

AU - Kaaks, Rudolf

AU - Von Rüsten, Anne

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Benetou, Vassiliki

AU - Grioni, Sara

AU - Panico, Salvatore

AU - Masala, Giovanna

AU - Tumino, Rosario

AU - Polidoro, Silvia

AU - Bakker, Marije F.

AU - Van Gils, Carla H.

AU - Ros, Martine M.

AU - Bueno-de-Mesquita, H. Bas

AU - Krum-Hansen, Sanda

AU - Engeset, Dagrun

AU - Skeie, Guri

AU - Pilar, Amiano

AU - Sánchez, Maria José

AU - Buckland, Genevieve

AU - Ardanaz, Eva

AU - Chirlaque, Dolores

AU - Rodriguez, Laudina

AU - Travis, Ruth

AU - Key, Tim

AU - Khaw, Kay Tee

AU - Wareham, Nicholas J.

AU - Sund, Malin

AU - Lenner, Per

AU - Slimani, Nadia

AU - Norat, Teresa

AU - Aune, Dagfinn

AU - Riboli, Elio

AU - Romieu, Isabelle

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Background: Limited scientific evidence has characterized the association between dietary fiber intake and risk of breast cancer (BC) by menopausal status and hormone receptor expression in tumors. Objective: We investigated the relation between total dietary fiber and its main food sources (vegetables fruit cereals and legumes) and BC risk by using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: A total of 11,576 invasive BC cases in 334,849 EPIC women mostly aged 35-70 y at baseline were identified over a median follow-up of 11.5 y. Dietary fiber was estimated from country-specific dietary questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk with energy adjustment by using the residual method. Subgroup analyses were performed by menopausal status and estrogen receptor (ER) and progesterone receptor (PR) expression in tumors. Results: BC risk was inversely associated with intakes of total dietary fiber [hazard ratio comparing fifth quintile to first quintile (HRQ5-Q1): 0.95; 95% CI: 0.89 1.01; P-trend = 0.03] and fiber from vegetables (0.90; 0.84 0.96; P-trend <0.01) but not with fiber from fruit cereals or legumes. Overall associations were homogeneous by menopausal status and ER and PR expression in tumors. For vegetable fiber stronger associations were observed for estrogen receptor-negative and progesterone receptor-negative (HRQ5-Q1:0.74; 95% CI: 0.59 0.93; P-trend = 0.01) than for estrogen receptor-positive and progesterone receptor-positive tumors (0.92: 0.81 1.03; P-trend = 0.05) with P-heterogeneity = 0.09. Conclusion: Diets rich in dietary fiber and particularly fiber from vegetables may be associated with a small reduction in risk of BC independently of menopausal status.

AB - Background: Limited scientific evidence has characterized the association between dietary fiber intake and risk of breast cancer (BC) by menopausal status and hormone receptor expression in tumors. Objective: We investigated the relation between total dietary fiber and its main food sources (vegetables fruit cereals and legumes) and BC risk by using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: A total of 11,576 invasive BC cases in 334,849 EPIC women mostly aged 35-70 y at baseline were identified over a median follow-up of 11.5 y. Dietary fiber was estimated from country-specific dietary questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk with energy adjustment by using the residual method. Subgroup analyses were performed by menopausal status and estrogen receptor (ER) and progesterone receptor (PR) expression in tumors. Results: BC risk was inversely associated with intakes of total dietary fiber [hazard ratio comparing fifth quintile to first quintile (HRQ5-Q1): 0.95; 95% CI: 0.89 1.01; P-trend = 0.03] and fiber from vegetables (0.90; 0.84 0.96; P-trend <0.01) but not with fiber from fruit cereals or legumes. Overall associations were homogeneous by menopausal status and ER and PR expression in tumors. For vegetable fiber stronger associations were observed for estrogen receptor-negative and progesterone receptor-negative (HRQ5-Q1:0.74; 95% CI: 0.59 0.93; P-trend = 0.01) than for estrogen receptor-positive and progesterone receptor-positive tumors (0.92: 0.81 1.03; P-trend = 0.05) with P-heterogeneity = 0.09. Conclusion: Diets rich in dietary fiber and particularly fiber from vegetables may be associated with a small reduction in risk of BC independently of menopausal status.

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