Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium

Chun Pin Chang, Carlo La Vecchia, Diego Serraino, Andrew F. Olshan, Jose P. Zevallos, Hal Morgenstern, Fabio Levi, Werner Garavello, Karl Kelsey, Michael McClean, Chu Chen, Stephen M. Schwartz, Stimson Schantz, Guo Pei Yu, Paolo Boffetta, Mia Hashibe, Yuan Chin Amy Lee, Maria Parpinel, Livia S.A. Augustin, Federica TuratiZuo Feng Zhang, Valeria Edefonti

Research output: Contribution to journalArticlepeer-review

Abstract

High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02–1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30–1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63–0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.

Original languageEnglish
Pages (from-to)745-748
Number of pages4
JournalBritish Journal of Cancer
Volume122
Issue number6
DOIs
Publication statusPublished - Mar 17 2020

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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