TY - JOUR
T1 - Dietary glycemic index and glycemic load and risk of pancreatic cancer
T2 - A case-control study
AU - Rossi, Marta
AU - Lipworth, Loren
AU - Polesel, Jerry
AU - Negri, Eva
AU - Bosetti, Cristina
AU - Talamini, Renato
AU - McLaughlin, Joseph K.
AU - La Vecchia, Carlo
PY - 2010/6
Y1 - 2010/6
N2 - Purpose: Carbohydrates and dietary glycemic index (GI) influence the secretion of insulin and insulin-related growth factors and may play a role in the development of diabetes and obesity, both of which have been related to pancreatic cancer risk. Methods: We examined the association between dietary GI and glycemic load (GL) and pancreatic cancer by conducting a hospital-based case-control study in Italy in 1991-2008 of 326 cases of pancreatic cancer and 652 control patients. Dietary data were obtained with the use of a validated food-frequency questionnaire. Odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were computed with the use of multiple logistic regression. Results: GI was positively associated with pancreatic cancer, with ORs of 1.56 (95% CI, 1.06-2.30) and 1.78 (95% CI, 1.20-2.62) for the second and third tertiles, respectively, compared with the lowest. No significant association was observed between GL and pancreatic cancer. Consumption of sugar, candy, honey, and jam was positively associated with pancreatic cancer, whereas consumption of fruit was inversely associated. Conclusions: In conclusion, the positive association with high GI, in the absence of an association with dietary GL, fruit, or total carbohydrates, likely reflects the positive association between sweets or refined carbohydrates and pancreatic cancer in this study population.
AB - Purpose: Carbohydrates and dietary glycemic index (GI) influence the secretion of insulin and insulin-related growth factors and may play a role in the development of diabetes and obesity, both of which have been related to pancreatic cancer risk. Methods: We examined the association between dietary GI and glycemic load (GL) and pancreatic cancer by conducting a hospital-based case-control study in Italy in 1991-2008 of 326 cases of pancreatic cancer and 652 control patients. Dietary data were obtained with the use of a validated food-frequency questionnaire. Odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were computed with the use of multiple logistic regression. Results: GI was positively associated with pancreatic cancer, with ORs of 1.56 (95% CI, 1.06-2.30) and 1.78 (95% CI, 1.20-2.62) for the second and third tertiles, respectively, compared with the lowest. No significant association was observed between GL and pancreatic cancer. Consumption of sugar, candy, honey, and jam was positively associated with pancreatic cancer, whereas consumption of fruit was inversely associated. Conclusions: In conclusion, the positive association with high GI, in the absence of an association with dietary GL, fruit, or total carbohydrates, likely reflects the positive association between sweets or refined carbohydrates and pancreatic cancer in this study population.
KW - Epidemiology
KW - Glycemic Index
KW - Glycemic Load
KW - Pancreatic Cancer
UR - http://www.scopus.com/inward/record.url?scp=77952763879&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952763879&partnerID=8YFLogxK
U2 - 10.1016/j.annepidem.2010.03.018
DO - 10.1016/j.annepidem.2010.03.018
M3 - Article
C2 - 20470973
AN - SCOPUS:77952763879
VL - 20
SP - 460
EP - 465
JO - Annals of Epidemiology
JF - Annals of Epidemiology
SN - 1047-2797
IS - 6
ER -