Dietary glycemic index, glycemic load and ovarian cancer risk: A case-control study in Italy

L. S A Augustin, J. Polesel, C. Bosetti, C. W C Kendall, C. La Vecchia, M. Parpinel, E. Conti, M. Montella, S. Franceschi, D. J A Jenkins, Luigino Dal Maso

Research output: Contribution to journalArticle

Abstract

Background: Dietary carbohydrates vary in their ability to raise blood glucose and insulin levels, which, in turn, influence levels of sex hormones and insulin-like growth factors. We analyzed the effect of type and amount of carbohydrates on ovarian cancer risk, using the glycemic index (GI) and the glycemic load (GL) measurement in a large case-control study conducted in Italy. Materials and methods: Cases included 1031 women with incident, histologically confirmed epithelial ovarian cancer, from four Italian regions. Controls included 2411 women admitted to the same hospital networks for acute, non-neoplastic conditions. Average daily GI and GL were calculated from a validated food frequency questionnaire. Odds ratios (OR) and the corresponding 95% confidence intervals (CI) were computed using multiple logistic regression. Results: Ovarian cancer was directly associated with dietary GI (OR for highest versus lowest quartile = 1.7, 95% CI 1.3-2.1) and GL (OR = 1.7, 95% CI 1.3-2.1). The associations were observed in pre- and post-menopausal women, and they remained consistent across strata of major covariates identified. Conclusions: This study supports the hypothesis of a direct association between GI and GL and ovarian cancer risk and, consequently, of a possible role of hyperinsulinemia/insulin resistance in ovarian cancer development.

Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalAnnals of Oncology
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

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Glycemic Index
Ovarian Neoplasms
Italy
Case-Control Studies
Odds Ratio
Confidence Intervals
Dietary Carbohydrates
Hyperinsulinism
Gonadal Steroid Hormones
Somatomedins
Insulin Resistance
Blood Glucose
Logistic Models
Carbohydrates
Insulin
Food
Glycemic Load

Keywords

  • Carbohydrate
  • Case-control study
  • Glycemic load
  • Ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Dietary glycemic index, glycemic load and ovarian cancer risk : A case-control study in Italy. / Augustin, L. S A; Polesel, J.; Bosetti, C.; Kendall, C. W C; La Vecchia, C.; Parpinel, M.; Conti, E.; Montella, M.; Franceschi, S.; Jenkins, D. J A; Dal Maso, Luigino.

In: Annals of Oncology, Vol. 14, No. 1, 01.01.2003, p. 78-84.

Research output: Contribution to journalArticle

Augustin, LSA, Polesel, J, Bosetti, C, Kendall, CWC, La Vecchia, C, Parpinel, M, Conti, E, Montella, M, Franceschi, S, Jenkins, DJA & Dal Maso, L 2003, 'Dietary glycemic index, glycemic load and ovarian cancer risk: A case-control study in Italy', Annals of Oncology, vol. 14, no. 1, pp. 78-84. https://doi.org/10.1093/annonc/dkg022
Augustin, L. S A ; Polesel, J. ; Bosetti, C. ; Kendall, C. W C ; La Vecchia, C. ; Parpinel, M. ; Conti, E. ; Montella, M. ; Franceschi, S. ; Jenkins, D. J A ; Dal Maso, Luigino. / Dietary glycemic index, glycemic load and ovarian cancer risk : A case-control study in Italy. In: Annals of Oncology. 2003 ; Vol. 14, No. 1. pp. 78-84.
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