Abstract
We investigated gastric cancer risk in relation to dietary glycemic index (GI) and glycemic load (GL), which represent indirect measures of carbohydrate absorption and consequently of dietary insulin demand, in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with the incident, histologically confirmed gastric cancer and 547 frequency matched controls, admitted to the same hospitals as cases with acute non-neoplastic conditions. We used conditional logistic regression models, including terms for major recognised gastric cancer risk factors and non-carbohydrate energy intake. The odds ratios (ORs) in the highest vs lowest quintile were 1.9 (95% CI: 1.0-3.3) for GI and 2.5 (95% CI: 1.3-4.9) for GL. Compared with participants reporting low GL and high fruits/vegetables intake, the OR rose across strata of high GL and low fruits/vegetables, to reach 5.0 (95% CI: 2.2-11.5) for those reporting low fruits/vegetables intake and high GL. Our study may help to explain the direct relation observed in several studies between starchy foods and gastric cancer risk.
| Original language | English |
|---|---|
| Pages (from-to) | 558-561 |
| Number of pages | 4 |
| Journal | British Journal of Cancer |
| Volume | 100 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Feb 10 2009 |
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Keywords
- Case-control studies
- Dietary glycemic load
- Gastric cancer
- Glycemic index
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Dietary glycemic load and gastric cancer risk in Italy. / Bertuccio, P.; Praud, D.; Chatenoud, L.; Lucenteforte, E.; Bosetti, C.; Pelucchi, C.; Rossi, M.; Negri, E.; La Vecchia, C.
In: British Journal of Cancer, Vol. 100, No. 3, 10.02.2009, p. 558-561.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dietary glycemic load and gastric cancer risk in Italy
AU - Bertuccio, P.
AU - Praud, D.
AU - Chatenoud, L.
AU - Lucenteforte, E.
AU - Bosetti, C.
AU - Pelucchi, C.
AU - Rossi, M.
AU - Negri, E.
AU - La Vecchia, C.
PY - 2009/2/10
Y1 - 2009/2/10
N2 - We investigated gastric cancer risk in relation to dietary glycemic index (GI) and glycemic load (GL), which represent indirect measures of carbohydrate absorption and consequently of dietary insulin demand, in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with the incident, histologically confirmed gastric cancer and 547 frequency matched controls, admitted to the same hospitals as cases with acute non-neoplastic conditions. We used conditional logistic regression models, including terms for major recognised gastric cancer risk factors and non-carbohydrate energy intake. The odds ratios (ORs) in the highest vs lowest quintile were 1.9 (95% CI: 1.0-3.3) for GI and 2.5 (95% CI: 1.3-4.9) for GL. Compared with participants reporting low GL and high fruits/vegetables intake, the OR rose across strata of high GL and low fruits/vegetables, to reach 5.0 (95% CI: 2.2-11.5) for those reporting low fruits/vegetables intake and high GL. Our study may help to explain the direct relation observed in several studies between starchy foods and gastric cancer risk.
AB - We investigated gastric cancer risk in relation to dietary glycemic index (GI) and glycemic load (GL), which represent indirect measures of carbohydrate absorption and consequently of dietary insulin demand, in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with the incident, histologically confirmed gastric cancer and 547 frequency matched controls, admitted to the same hospitals as cases with acute non-neoplastic conditions. We used conditional logistic regression models, including terms for major recognised gastric cancer risk factors and non-carbohydrate energy intake. The odds ratios (ORs) in the highest vs lowest quintile were 1.9 (95% CI: 1.0-3.3) for GI and 2.5 (95% CI: 1.3-4.9) for GL. Compared with participants reporting low GL and high fruits/vegetables intake, the OR rose across strata of high GL and low fruits/vegetables, to reach 5.0 (95% CI: 2.2-11.5) for those reporting low fruits/vegetables intake and high GL. Our study may help to explain the direct relation observed in several studies between starchy foods and gastric cancer risk.
KW - Case-control studies
KW - Dietary glycemic load
KW - Gastric cancer
KW - Glycemic index
UR - http://www.scopus.com/inward/record.url?scp=59649124839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=59649124839&partnerID=8YFLogxK
U2 - 10.1038/sj.bjc.6604894
DO - 10.1038/sj.bjc.6604894
M3 - Article
C2 - 19190635
AN - SCOPUS:59649124839
VL - 100
SP - 558
EP - 561
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 3
ER -