Dietary glycemic load and gastric cancer risk in Italy

P. Bertuccio, D. Praud, L. Chatenoud, E. Lucenteforte, C. Bosetti, C. Pelucchi, M. Rossi, E. Negri, C. La Vecchia

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We investigated gastric cancer risk in relation to dietary glycemic index (GI) and glycemic load (GL), which represent indirect measures of carbohydrate absorption and consequently of dietary insulin demand, in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with the incident, histologically confirmed gastric cancer and 547 frequency matched controls, admitted to the same hospitals as cases with acute non-neoplastic conditions. We used conditional logistic regression models, including terms for major recognised gastric cancer risk factors and non-carbohydrate energy intake. The odds ratios (ORs) in the highest vs lowest quintile were 1.9 (95% CI: 1.0-3.3) for GI and 2.5 (95% CI: 1.3-4.9) for GL. Compared with participants reporting low GL and high fruits/vegetables intake, the OR rose across strata of high GL and low fruits/vegetables, to reach 5.0 (95% CI: 2.2-11.5) for those reporting low fruits/vegetables intake and high GL. Our study may help to explain the direct relation observed in several studies between starchy foods and gastric cancer risk.

Original languageEnglish
Pages (from-to)558-561
Number of pages4
JournalBritish Journal of Cancer
Volume100
Issue number3
DOIs
Publication statusPublished - Feb 10 2009

Fingerprint

Italy
Stomach Neoplasms
Vegetables
Glycemic Index
Fruit
Logistic Models
Odds Ratio
Energy Intake
Case-Control Studies
Carbohydrates
Glycemic Load
Insulin
Food

Keywords

  • Case-control studies
  • Dietary glycemic load
  • Gastric cancer
  • Glycemic index

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bertuccio, P., Praud, D., Chatenoud, L., Lucenteforte, E., Bosetti, C., Pelucchi, C., ... La Vecchia, C. (2009). Dietary glycemic load and gastric cancer risk in Italy. British Journal of Cancer, 100(3), 558-561. https://doi.org/10.1038/sj.bjc.6604894

Dietary glycemic load and gastric cancer risk in Italy. / Bertuccio, P.; Praud, D.; Chatenoud, L.; Lucenteforte, E.; Bosetti, C.; Pelucchi, C.; Rossi, M.; Negri, E.; La Vecchia, C.

In: British Journal of Cancer, Vol. 100, No. 3, 10.02.2009, p. 558-561.

Research output: Contribution to journalArticle

Bertuccio, P, Praud, D, Chatenoud, L, Lucenteforte, E, Bosetti, C, Pelucchi, C, Rossi, M, Negri, E & La Vecchia, C 2009, 'Dietary glycemic load and gastric cancer risk in Italy', British Journal of Cancer, vol. 100, no. 3, pp. 558-561. https://doi.org/10.1038/sj.bjc.6604894
Bertuccio, P. ; Praud, D. ; Chatenoud, L. ; Lucenteforte, E. ; Bosetti, C. ; Pelucchi, C. ; Rossi, M. ; Negri, E. ; La Vecchia, C. / Dietary glycemic load and gastric cancer risk in Italy. In: British Journal of Cancer. 2009 ; Vol. 100, No. 3. pp. 558-561.
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