Dietary habits and neurological features of Parkinson's disease patients: Implications for practice

Michela Barichella, Emanuele Cereda, Erica Cassani, Giovanna Pinelli, Laura Iorio, Valentina Ferri, Giulia Privitera, Marianna Pasqua, Angela Valentino, Fatemeh Monajemi, Serena Caronni, Caterina Lignola, Chiara Pusani, Carlotta Bolliri, Samanta A. Faierman, Alessandro Lubisco, Giuseppe Frazzitta, Maria L. Petroni, Gianni Pezzoli

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background & aims Parkinson's disease (PD) patients can benefit considerably from appropriate nutritional care, particularly from diet. However, there is limited evidence on the eating habits of PD patients and their relationship with the features of the disease. Methods We conducted a large case–control study. Consecutive PD patients (N = 600) receiving systematic nutritional care and healthy controls (N = 600) matched (1:1) for age, gender, education, physical activity level and residence were studied using a 66-item food frequency questionnaire. The relationship between dietary habits and the following features of PD were investigated in patients: body weight, energy balance, constipation, and levodopa therapy (dose) and its related motor complications. Results PD patients had lower BMI and reported higher food intake than controls. BMI was found to be inversely associated with disease duration and severity, and levodopa-related motor complications, whereas energy intake was positively associated with these variables. An increase in protein intake by 10 g over physiological requirements (0.8 g/kg/day) corresponded to a mean increase in levodopa dose of 0.7 mg/kg/day. Constipation was also associated with higher levodopa requirements. Finally, protein intake and its distribution throughout the day influenced levodopa-related motor complications. Conclusion The management of protein intake and the treatment of constipation should be considered to be an integral part of the care of PD patients. Attention should always be focused on energy intake also. This would result in the maintenance of nutritional status, the optimization of levodopa-therapy and the minimization of its related motor complications.

Original languageEnglish
Pages (from-to)1054-1061
Number of pages8
JournalClinical Nutrition
Volume36
Issue number4
DOIs
Publication statusPublished - Aug 1 2017

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Levodopa
Feeding Behavior
Parkinson Disease
Constipation
Energy Intake
Proteins
Nutritional Status
Therapeutics
Eating
Body Weight
Maintenance
Exercise
Diet
Education
Food

Keywords

  • Body weight
  • Diet
  • Gastrointestinal dysfunction
  • Levodopa
  • Motor fluctuations
  • Parkinson's disease

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Critical Care and Intensive Care Medicine

Cite this

Dietary habits and neurological features of Parkinson's disease patients : Implications for practice. / Barichella, Michela; Cereda, Emanuele; Cassani, Erica; Pinelli, Giovanna; Iorio, Laura; Ferri, Valentina; Privitera, Giulia; Pasqua, Marianna; Valentino, Angela; Monajemi, Fatemeh; Caronni, Serena; Lignola, Caterina; Pusani, Chiara; Bolliri, Carlotta; Faierman, Samanta A.; Lubisco, Alessandro; Frazzitta, Giuseppe; Petroni, Maria L.; Pezzoli, Gianni.

In: Clinical Nutrition, Vol. 36, No. 4, 01.08.2017, p. 1054-1061.

Research output: Contribution to journalArticle

Barichella, M, Cereda, E, Cassani, E, Pinelli, G, Iorio, L, Ferri, V, Privitera, G, Pasqua, M, Valentino, A, Monajemi, F, Caronni, S, Lignola, C, Pusani, C, Bolliri, C, Faierman, SA, Lubisco, A, Frazzitta, G, Petroni, ML & Pezzoli, G 2017, 'Dietary habits and neurological features of Parkinson's disease patients: Implications for practice', Clinical Nutrition, vol. 36, no. 4, pp. 1054-1061. https://doi.org/10.1016/j.clnu.2016.06.020
Barichella, Michela ; Cereda, Emanuele ; Cassani, Erica ; Pinelli, Giovanna ; Iorio, Laura ; Ferri, Valentina ; Privitera, Giulia ; Pasqua, Marianna ; Valentino, Angela ; Monajemi, Fatemeh ; Caronni, Serena ; Lignola, Caterina ; Pusani, Chiara ; Bolliri, Carlotta ; Faierman, Samanta A. ; Lubisco, Alessandro ; Frazzitta, Giuseppe ; Petroni, Maria L. ; Pezzoli, Gianni. / Dietary habits and neurological features of Parkinson's disease patients : Implications for practice. In: Clinical Nutrition. 2017 ; Vol. 36, No. 4. pp. 1054-1061.
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abstract = "Background & aims Parkinson's disease (PD) patients can benefit considerably from appropriate nutritional care, particularly from diet. However, there is limited evidence on the eating habits of PD patients and their relationship with the features of the disease. Methods We conducted a large case–control study. Consecutive PD patients (N = 600) receiving systematic nutritional care and healthy controls (N = 600) matched (1:1) for age, gender, education, physical activity level and residence were studied using a 66-item food frequency questionnaire. The relationship between dietary habits and the following features of PD were investigated in patients: body weight, energy balance, constipation, and levodopa therapy (dose) and its related motor complications. Results PD patients had lower BMI and reported higher food intake than controls. BMI was found to be inversely associated with disease duration and severity, and levodopa-related motor complications, whereas energy intake was positively associated with these variables. An increase in protein intake by 10 g over physiological requirements (0.8 g/kg/day) corresponded to a mean increase in levodopa dose of 0.7 mg/kg/day. Constipation was also associated with higher levodopa requirements. Finally, protein intake and its distribution throughout the day influenced levodopa-related motor complications. Conclusion The management of protein intake and the treatment of constipation should be considered to be an integral part of the care of PD patients. Attention should always be focused on energy intake also. This would result in the maintenance of nutritional status, the optimization of levodopa-therapy and the minimization of its related motor complications.",
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AU - Barichella, Michela

AU - Cereda, Emanuele

AU - Cassani, Erica

AU - Pinelli, Giovanna

AU - Iorio, Laura

AU - Ferri, Valentina

AU - Privitera, Giulia

AU - Pasqua, Marianna

AU - Valentino, Angela

AU - Monajemi, Fatemeh

AU - Caronni, Serena

AU - Lignola, Caterina

AU - Pusani, Chiara

AU - Bolliri, Carlotta

AU - Faierman, Samanta A.

AU - Lubisco, Alessandro

AU - Frazzitta, Giuseppe

AU - Petroni, Maria L.

AU - Pezzoli, Gianni

PY - 2017/8/1

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N2 - Background & aims Parkinson's disease (PD) patients can benefit considerably from appropriate nutritional care, particularly from diet. However, there is limited evidence on the eating habits of PD patients and their relationship with the features of the disease. Methods We conducted a large case–control study. Consecutive PD patients (N = 600) receiving systematic nutritional care and healthy controls (N = 600) matched (1:1) for age, gender, education, physical activity level and residence were studied using a 66-item food frequency questionnaire. The relationship between dietary habits and the following features of PD were investigated in patients: body weight, energy balance, constipation, and levodopa therapy (dose) and its related motor complications. Results PD patients had lower BMI and reported higher food intake than controls. BMI was found to be inversely associated with disease duration and severity, and levodopa-related motor complications, whereas energy intake was positively associated with these variables. An increase in protein intake by 10 g over physiological requirements (0.8 g/kg/day) corresponded to a mean increase in levodopa dose of 0.7 mg/kg/day. Constipation was also associated with higher levodopa requirements. Finally, protein intake and its distribution throughout the day influenced levodopa-related motor complications. Conclusion The management of protein intake and the treatment of constipation should be considered to be an integral part of the care of PD patients. Attention should always be focused on energy intake also. This would result in the maintenance of nutritional status, the optimization of levodopa-therapy and the minimization of its related motor complications.

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KW - Gastrointestinal dysfunction

KW - Levodopa

KW - Motor fluctuations

KW - Parkinson's disease

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