TY - JOUR
T1 - Dietary habits and risk of pancreatic cancer
T2 - An Italian case-control study
AU - Polesel, Jerry
AU - Talamini, Renato
AU - Negri, Eva
AU - Bosetti, Cristina
AU - Boz, Giovanni
AU - Lucenteforte, Ersilia
AU - Franceschi, Silvia
AU - Serraino, Diego
AU - La Vecchia, Carlo
PY - 2010/4
Y1 - 2010/4
N2 - Objective To investigate the association between dietary habits and pancreatic cancer. Methods Between 1991 and 2008, we conducted a hospitalbased case-control study in northern Italy. Cases: 326 patients (median age 63 years) with incident pancreatic cancer admitted to general hospitals in the areas of Milan and Pordenone, northern Italy. Controls: 652 patients (median age 63 years) with acute non-neoplastic conditions admitted to the same hospital network of cases. Diet was assessed using a validated food frequency questionnaire. Conditional logistic regression was used to estimate odds ratios (OR) and the corresponding 95% confidence intervals (CI). Results Frequent meat consumption was associated to a twofold increased risk of pancreatic cancer (95% CI: 1.18-3.36); the risk was significant for meat cooked by boiling/ stewing or broiling/roasting. Added table sugar (OR = 2.23; 95% CI: 1.34-3.71) and potatoes (OR = 1.79; 95% CI: 1.12-2.86) were related to pancreatic cancer. An inverse association emerged for non-citrus fruits (OR = 0.41; 95% CI: 0.24-0.69), cooked vegetables (OR = 0.57; 95% CI: 0.36-0.92), and, possibly, for pulses (OR = 0.59; 95% CI: 0.35-1.00). Conclusions The present study supports an inverse association between fruits and vegetables and pancreatic cancer risk, and it confirms a direct relation with meat. The increased risk for table sugar suggests that insulin resistance may play a role in pancreatic carcinogenesis.
AB - Objective To investigate the association between dietary habits and pancreatic cancer. Methods Between 1991 and 2008, we conducted a hospitalbased case-control study in northern Italy. Cases: 326 patients (median age 63 years) with incident pancreatic cancer admitted to general hospitals in the areas of Milan and Pordenone, northern Italy. Controls: 652 patients (median age 63 years) with acute non-neoplastic conditions admitted to the same hospital network of cases. Diet was assessed using a validated food frequency questionnaire. Conditional logistic regression was used to estimate odds ratios (OR) and the corresponding 95% confidence intervals (CI). Results Frequent meat consumption was associated to a twofold increased risk of pancreatic cancer (95% CI: 1.18-3.36); the risk was significant for meat cooked by boiling/ stewing or broiling/roasting. Added table sugar (OR = 2.23; 95% CI: 1.34-3.71) and potatoes (OR = 1.79; 95% CI: 1.12-2.86) were related to pancreatic cancer. An inverse association emerged for non-citrus fruits (OR = 0.41; 95% CI: 0.24-0.69), cooked vegetables (OR = 0.57; 95% CI: 0.36-0.92), and, possibly, for pulses (OR = 0.59; 95% CI: 0.35-1.00). Conclusions The present study supports an inverse association between fruits and vegetables and pancreatic cancer risk, and it confirms a direct relation with meat. The increased risk for table sugar suggests that insulin resistance may play a role in pancreatic carcinogenesis.
KW - Added sugar
KW - Diet
KW - Meat
KW - Pancreatic cancer
KW - Risk factors
KW - Vegetables
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U2 - 10.1007/s10552-009-9480-2
DO - 10.1007/s10552-009-9480-2
M3 - Article
C2 - 20091114
AN - SCOPUS:77952784245
VL - 21
SP - 493
EP - 500
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 4
ER -