Dietary inflammatory index and endometrial cancer risk in an Italian case-control study

Nitin Shivappa, James R. Hébert, Antonella Zucchetto, Maurizio Montella, Diego Serraino, Carlo La Vecchia, Marta Rossi

Research output: Contribution to journalArticle

Abstract

The relation between inflammation deriving from diet and endometrial cancer risk has not yet been investigated. In this study, we explored the association between the dietary inflammatory index (DII) and endometrial cancer risk in an Italian case-control study. Cases comprised 454 patients with incident, histologically confirmed carcinoma of the endometrium, and controls comprised 908 subjects admitted to the same network of hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. DII scores were computed on the basis of dietary intake assessed using a reproducible and valid seventy-eight-item FFQ. OR were calculated through logistic regression models conditioned on age and study centre and adjusted for recognised confounding factors, including total energy intake. Women with the most pro-inflammatory diet had a higher risk for endometrial cancer compared with women with the most anti-inflammatory diet (ORQuartile 4 v. 1 1·46; 95 % CI 1·02, 2·11; P trend=0·04). A pro-inflammatory diet may increase the risk for endometrial cancer.

Original languageEnglish
Pages (from-to)138-146
Number of pages9
JournalBritish Journal of Nutrition
Volume115
Issue number1
DOIs
Publication statusPublished - Jan 2016

Keywords

  • Case-control studies
  • Diet
  • Dietary inflammatory index
  • Endometrial cancer
  • Inflammation
  • Italy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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