Dietary Inflammatory Index and Risk of Bladder Cancer in a Large Italian Case-control Study

Nitin Shivappa, James R. Hébert, Valentina Rosato, Marta Rossi, Massimo Libra, Maurizio Montella, Carlo La Vecchia

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: To evaluate the association between diet in relation to its inflammatory property and bladder cancer (BC) risk. Methods: In this study we explored the association between the dietary inflammatory index (DII) and BC risk in an Italian case-control study conducted between 2003 and 2014. Cases were 690 patients with incident and histologically confirmed BC from 4 areas in Italy. Controls were 665 cancer-free subjects admitted to the same network of hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. The DII was computed based on dietary intake assessed using a reproducible and valid 80-item food frequency questionnaire. Odds ratios (OR) were estimated through logistic regression models adjusting for age, sex, total energy intake, and other recognized confounding factors. Results: Subjects in the highest quartile of DII scores (ie, with a more pro-inflammatory diet) had a higher risk of BC compared to subjects in the lowest quartile (ie, with an anti-inflammatory diet) (ORQuartile4vs1 = 1.97; 95% [confidence interval], 1.28, 3.03; P trend = .003). Stratified analyses produced stronger associations between DII and BC risk among females (ORQuartile4vs1 = 5.73; 95% CI = 1.46, 22.44), older ≥65 years (ORQuartile4vs1 = 2.45; 95% CI = 1.38, 4.34), subjects with higher education ≥7 years (ORQuartile4vs1 = 2.22; 95% CI = 1.27, 3.88), and never smokers (ORQuartile4vs1 = 4.04; 95% CI = 1.51, 10.80). Conclusion: A pro-inflammatory diet as indicated by higher DII scores is associated with increased BC risk.

Original languageEnglish
JournalUrology
DOIs
Publication statusPublished - 2017

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Urinary Bladder Neoplasms
Case-Control Studies
Diet
Logistic Models
Energy Intake
Italy
Anti-Inflammatory Agents
Odds Ratio
Confidence Intervals
Education
Food
Neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Dietary Inflammatory Index and Risk of Bladder Cancer in a Large Italian Case-control Study. / Shivappa, Nitin; Hébert, James R.; Rosato, Valentina; Rossi, Marta; Libra, Massimo; Montella, Maurizio; La Vecchia, Carlo.

In: Urology, 2017.

Research output: Contribution to journalArticle

Shivappa, Nitin ; Hébert, James R. ; Rosato, Valentina ; Rossi, Marta ; Libra, Massimo ; Montella, Maurizio ; La Vecchia, Carlo. / Dietary Inflammatory Index and Risk of Bladder Cancer in a Large Italian Case-control Study. In: Urology. 2017.
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title = "Dietary Inflammatory Index and Risk of Bladder Cancer in a Large Italian Case-control Study",
abstract = "Objective: To evaluate the association between diet in relation to its inflammatory property and bladder cancer (BC) risk. Methods: In this study we explored the association between the dietary inflammatory index (DII) and BC risk in an Italian case-control study conducted between 2003 and 2014. Cases were 690 patients with incident and histologically confirmed BC from 4 areas in Italy. Controls were 665 cancer-free subjects admitted to the same network of hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. The DII was computed based on dietary intake assessed using a reproducible and valid 80-item food frequency questionnaire. Odds ratios (OR) were estimated through logistic regression models adjusting for age, sex, total energy intake, and other recognized confounding factors. Results: Subjects in the highest quartile of DII scores (ie, with a more pro-inflammatory diet) had a higher risk of BC compared to subjects in the lowest quartile (ie, with an anti-inflammatory diet) (ORQuartile4vs1 = 1.97; 95{\%} [confidence interval], 1.28, 3.03; P trend = .003). Stratified analyses produced stronger associations between DII and BC risk among females (ORQuartile4vs1 = 5.73; 95{\%} CI = 1.46, 22.44), older ≥65 years (ORQuartile4vs1 = 2.45; 95{\%} CI = 1.38, 4.34), subjects with higher education ≥7 years (ORQuartile4vs1 = 2.22; 95{\%} CI = 1.27, 3.88), and never smokers (ORQuartile4vs1 = 4.04; 95{\%} CI = 1.51, 10.80). Conclusion: A pro-inflammatory diet as indicated by higher DII scores is associated with increased BC risk.",
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N2 - Objective: To evaluate the association between diet in relation to its inflammatory property and bladder cancer (BC) risk. Methods: In this study we explored the association between the dietary inflammatory index (DII) and BC risk in an Italian case-control study conducted between 2003 and 2014. Cases were 690 patients with incident and histologically confirmed BC from 4 areas in Italy. Controls were 665 cancer-free subjects admitted to the same network of hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. The DII was computed based on dietary intake assessed using a reproducible and valid 80-item food frequency questionnaire. Odds ratios (OR) were estimated through logistic regression models adjusting for age, sex, total energy intake, and other recognized confounding factors. Results: Subjects in the highest quartile of DII scores (ie, with a more pro-inflammatory diet) had a higher risk of BC compared to subjects in the lowest quartile (ie, with an anti-inflammatory diet) (ORQuartile4vs1 = 1.97; 95% [confidence interval], 1.28, 3.03; P trend = .003). Stratified analyses produced stronger associations between DII and BC risk among females (ORQuartile4vs1 = 5.73; 95% CI = 1.46, 22.44), older ≥65 years (ORQuartile4vs1 = 2.45; 95% CI = 1.38, 4.34), subjects with higher education ≥7 years (ORQuartile4vs1 = 2.22; 95% CI = 1.27, 3.88), and never smokers (ORQuartile4vs1 = 4.04; 95% CI = 1.51, 10.80). Conclusion: A pro-inflammatory diet as indicated by higher DII scores is associated with increased BC risk.

AB - Objective: To evaluate the association between diet in relation to its inflammatory property and bladder cancer (BC) risk. Methods: In this study we explored the association between the dietary inflammatory index (DII) and BC risk in an Italian case-control study conducted between 2003 and 2014. Cases were 690 patients with incident and histologically confirmed BC from 4 areas in Italy. Controls were 665 cancer-free subjects admitted to the same network of hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. The DII was computed based on dietary intake assessed using a reproducible and valid 80-item food frequency questionnaire. Odds ratios (OR) were estimated through logistic regression models adjusting for age, sex, total energy intake, and other recognized confounding factors. Results: Subjects in the highest quartile of DII scores (ie, with a more pro-inflammatory diet) had a higher risk of BC compared to subjects in the lowest quartile (ie, with an anti-inflammatory diet) (ORQuartile4vs1 = 1.97; 95% [confidence interval], 1.28, 3.03; P trend = .003). Stratified analyses produced stronger associations between DII and BC risk among females (ORQuartile4vs1 = 5.73; 95% CI = 1.46, 22.44), older ≥65 years (ORQuartile4vs1 = 2.45; 95% CI = 1.38, 4.34), subjects with higher education ≥7 years (ORQuartile4vs1 = 2.22; 95% CI = 1.27, 3.88), and never smokers (ORQuartile4vs1 = 4.04; 95% CI = 1.51, 10.80). Conclusion: A pro-inflammatory diet as indicated by higher DII scores is associated with increased BC risk.

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