Dietary Inflammatory Index and Risk of Bladder Cancer in a Large Italian Case-control Study

N. Shivappa, J.R. Hébert, V. Rosato, M. Rossi, M. Libra, M. Montella, D. Serraino, C. La Vecchia

Research output: Contribution to journalArticle

Abstract

Objective To evaluate the association between diet in relation to its inflammatory property and bladder cancer (BC) risk. Methods In this study we explored the association between the dietary inflammatory index (DII) and BC risk in an Italian case-control study conducted between 2003 and 2014. Cases were 690 patients with incident and histologically confirmed BC from 4 areas in Italy. Controls were 665 cancer-free subjects admitted to the same network of hospitals as cases for a wide spectrum of acute, non-neoplastic conditions. The DII was computed based on dietary intake assessed using a reproducible and valid 80-item food frequency questionnaire. Odds ratios (OR) were estimated through logistic regression models adjusting for age, sex, total energy intake, and other recognized confounding factors. Results Subjects in the highest quartile of DII scores (ie, with a more pro-inflammatory diet) had a higher risk of BC compared to subjects in the lowest quartile (ie, with an anti-inflammatory diet) (ORQuartile4vs1 = 1.97; 95% [confidence interval], 1.28, 3.03; P trend = .003). Stratified analyses produced stronger associations between DII and BC risk among females (ORQuartile4vs1 = 5.73; 95% CI = 1.46, 22.44), older ≥65 years (ORQuartile4vs1 = 2.45; 95% CI = 1.38, 4.34), subjects with higher education ≥7 years (ORQuartile4vs1 = 2.22; 95% CI = 1.27, 3.88), and never smokers (ORQuartile4vs1 = 4.04; 95% CI = 1.51, 10.80). Conclusion A pro-inflammatory diet as indicated by higher DII scores is associated with increased BC risk. © 2016 Elsevier Inc.
Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalUrology
Volume100
DOIs
Publication statusPublished - 2017

Keywords

  • alcohol
  • alpha tocopherol
  • ascorbic acid
  • beta carotene
  • carbohydrate
  • cholesterol
  • fat
  • flavanone derivative
  • flavone derivative
  • flavonol derivative
  • folic acid
  • iron
  • isoflavone derivative
  • monounsaturated fatty acid
  • nicotinic acid
  • omega 3 fatty acid
  • omega 6 fatty acid
  • polyunsaturated fatty acid
  • proanthocyanidin
  • protein
  • pyridoxine
  • retinol
  • riboflavin
  • saturated fatty acid
  • thiamine
  • vitamin D
  • zinc
  • adult
  • aged
  • Article
  • bladder cancer
  • caloric intake
  • cancer risk
  • case control study
  • clinical evaluation
  • controlled study
  • diet supplementation
  • dietary inflammatory index
  • dietary intake
  • disease association
  • educational status
  • female
  • food frequency questionnaire
  • histopathology
  • hospital admission
  • human
  • human tissue
  • major clinical study
  • male
  • middle aged
  • multicenter study
  • nutritional assessment
  • priority journal
  • risk assessment
  • risk factor
  • sex
  • smoking
  • tea

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