Dietary inflammatory index and risk of pancreatic cancer in an Italian case-control study

Nitin Shivappa, Cristina Bosetti, Antonella Zucchetto, Diego Serraino, Carlo La Vecchia, James R. Hébert

Research output: Contribution to journalArticlepeer-review

Abstract

Previous studies have shown that various dietary components may be implicated in the aetiology of pancreatic cancer. However, the possible relationship between diet-related inflammation and the risk of pancreatic cancer has not yet been investigated. We examined the ability of a newly developed literature-derived dietary inflammatory index (DII) to predict the risk of pancreatic cancer in a case-control study conducted in Italy between 1991 and 2008. This included 326 incident cases and 652 controls admitted to the major teaching and general hospitals for non-neoplastic diseases, frequency-matched to cases by study centre, sex and age. The DII was computed based on dietary intake assessed using a validated and reproducible seventy-eight-item FFQ. Logistic regression models were used to estimate multivariable OR adjusted for age, sex, study centre, education, BMI, smoking status, alcohol drinking and history of diabetes. Energy adjustment was performed using the residual method. Subjects with higher DII scores (i.e. representing a more pro-inflammatory diet) had a higher risk of pancreatic cancer, with the DII being used as both a continuous variable (ORcontinuous 1·24, 95 % CI 1·11, 1·38) and a categorical variable (i.e. compared with the subjects in the lowest quintile of the DII, those in the second, third, fourth and fifth quintiles had, respectively, ORquintile2 v. 1 1·70, 95 % CI 1·02, 2·80; ORquintile3 v. 1 1·91, 95 % CI 1·16, 3·16; ORquintile4 v. 1 1·98, 95 % CI 1·20, 3·27; ORquintile5 v. 1 2·48, 95 % CI 1·50, 4·10; P trend= 0·0015). These data suggest that a pro-inflammatory diet increases the risk of pancreatic cancer.

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalBritish Journal of Nutrition
Volume113
Issue number2
DOIs
Publication statusPublished - Jan 28 2015

Keywords

  • Case-control studies
  • Diet
  • Inflammation
  • Italy
  • Pancreatic cancer
  • Risk

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Dietary inflammatory index and risk of pancreatic cancer in an Italian case-control study'. Together they form a unique fingerprint.

Cite this